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Diss Factsheets
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EC number: 948-034-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not specified
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Remarks:
- as described by the FDA (21 CFR Part 58), 16 CFR 1500.3 and FDRL Standard Operating Procedures.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium octane-1-sulphonate monohydrate
- EC Number:
- 226-195-4
- EC Name:
- Sodium octane-1-sulphonate monohydrate
- Cas Number:
- 5324-84-5
- Molecular formula:
- C8H18O3S.Na
- IUPAC Name:
- sodium octane-1-sulfonate hydrate
Constituent 1
- Specific details on test material used for the study:
- FDRL Test Article ID: 85-0506
Sponsor Test Article ID: Sample No. 910-77
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Inc., Wilmington, MA
- Age at study initiation: 'young', not further specified
- Weight at study initiation: 255.4 ± 9.3 (males), 219.4 ± 13.0 (females)
- Fasting period before study: Food was withheld the night prior to dosing
- Housing: Animals were individually housed in wire mesh bottom cages in environment-controlled rooms
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- On the first day of the study, animals received a single oral dose by gavage of the test article at a level of 5.0 g/kg body weight.
- Doses:
- 5 g/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: Animals were weighed prior to dosing and at termination of the study or at necropsy. They were observed frequently on the day of dosing and daily thereafter for a total of 15 days. All external signs of toxicity or pharmacological effects were noted.
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 0 - < 27
- Remarks on result:
- other: only one dose tested
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: only one dose tested
- Mortality:
- 0 %; 0 of 10 rats died within the 15 day observation period
- Clinical signs:
- other: No clinical signs observed. All animals appeared normal throughout the study.
- Gross pathology:
- no pathology performed
- Other findings:
- no details given
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the acute toxicity study in rats no mortality was observed at 5 g/kg bw (LD50 > 5000 mg/kg bw).
- Executive summary:
Sodium octane-1-sulphonate monohydrate (EC: 226-195-4; CAS: 5324-84-5) was evaluated for acute oral toxicity in five male and five female Sprague-Dawley rats similar to OECD Guideline 401. The test article was administered by gavage to each of ten rats at a level of 5.0 g/kg body weight. All animals survived the 15 day post-administration observation period. No clinical signs of toxicity were observed during the observation period. Therefore the LD50 value is > 5000 mg/kg bw.
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