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EC number: 617-365-2 | CAS number: 82597-69-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984-01-10 to 1984-03-31
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Remarks:
- based on the guideline issued 1984-04-04. Some newer requirements of the 2004-04-13 issue (water contaminants and hardness) are not met.
- GLP compliance:
- yes
Test material
- Reference substance name:
- reaction mass of (1R,3R)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylic acid and (1S,3S)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylic acid
- EC Number:
- 614-283-9
- Cas Number:
- 68127-59-3
- Molecular formula:
- C9H10ClF3O2
- IUPAC Name:
- reaction mass of (1R,3R)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylic acid and (1S,3S)-3-[(1Z)-2-chloro-3,3,3-trifluoroprop-1-en-1-yl]-2,2-dimethylcyclopropanecarboxylic acid
- Details on test material:
- - Physical state: powder
- Colour: white
- Expiration date of the lot/batch: not reported
- Storage condition of test material: not reported (reference sample stored <5°C)
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: A stock solution (200 ppm, equivalent to mg/L) was prepared at the beginning of the experiment, and used as such or appropriately diluted to yield nominal tank concentrations of 30, 50, 80, 130, and 200 ppm.
- Sampling method: Samples were taken from each tank (3 replicates per dose, 2 subsequent studies) at the beginning (0 h) and the end (48 h) of exposure, and diluted with water to yield samples containing 8 - 15 ppm of the test substance.
- Sample storage conditions before analysis: not reported
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Stock solution of test material (500 mg) in dilution water (2.5 L), by mechanical dispersion (probably vigorous); further dilution to yield the lower nominal tank concentrations of 30, 50, 80, and 130 ppm.
- Test solutions prepared once, at the beginning of the experiment (static bioassay)
- Controls: freshwater control
- Evidence of undissolved material (e.g. precipitate, surface film, etc): None. Analytically determined values at 0 hours were practically identical with nominal concentrations (100 +/- 4%), at 48 hours even slightly higher (106 +/- 6%)
Test organisms
- Test organisms (species):
- Daphnia pulex
- Details on test organisms:
- TEST ORGANISM
- Common name: daphnia
- Age at study initiation: First instar, less than 24 hours
- Weight and length at study initiation (mean and range, SD): not applicable to daphnia
- Method of breeding: 50 parent Daphnia kept in 2-L holding tank on-site (20+/-1°C, 1000 Lux, 16hr light / 8hr dark period); diet: Selenastrum capricornutum (7.5x10exp8 per tank per day). First instars from 3 - 4 week old parent daphnia used in the test.
- Feeding during test: no
ACCLIMATION
- Acclimation period: none; breeding conditions same as test
QUARANTINE (wild caught): No, daphnia bred on site
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- 24-h results also reported
- Post exposure observation period:
- None reported
Test conditions
- Hardness:
- Hardness: 48.8 mg/L as CaCO3
Alkalinity: 45.6 mg/L as HCO3-
Conductivity: 121 micro-Siemens/cm - Test temperature:
- 20 +/- 1°C (min 19.4°C, max 20.3°C)
- pH:
- 7.3 - 7.6 at 0 hours, 6.4 - 7.5 at 48 hours
- Dissolved oxygen:
- 7.8 - 8.4 mg/L at 0 hours, 6.2 - 7.8 mg/L at 48 hours
- Salinity:
- Not determined (freshwater)
- Nominal and measured concentrations:
- Nominal: 30, 50, 80, 130, 200 ppm (equivalent to mg/L, assuming water density = 1 kg/L)
Analytical (0 h, 1st / 2nd study, average of 3 tanks each): 31 / 28 ppm, 53 / 51 ppm, 76 / 82 ppm, 130 / 127 ppm, 198 / 196 ppm
Analytical (48 h, 1st / 2nd study, average of 3 tanks each): 33 / 32 ppm, 51 / 48 ppm, 83 / 88 ppm, 136 / 144 ppm, 217 / 220 ppm
Controls: all measurements below LOD (<0.5 ppm) - Details on test conditions:
- TEST SYSTEM
- Test vessel: cylindrical aquarium, open
- Material, size, headspace, fill volume: all glass, diameter 7.4 cm, height 10 cm, nominal volume 300 mL, fill volume 250 mL
- Aeration: dilution water aerated before introduction into test tanks, no aeration during test
- Renewal rate of test solution (frequency): 0 (static)
- No. of independent studies: 2 (subsequent)
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 3 per study (total 6)
- No. of vessels per control (replicates): 3 per study (total 6)
- Biomass loading rate: not reported
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: tap water, dechlorinated with activated charcoal and heated to 20°C, then aerated prior to introduction into the test tanks.
- Dissolved oxygen: 8.2 mg/L
- Total organic carbon: 3.2 mg/L
- Particulate matter: suspended solids <0.1 mg/L
- Metals (mg/L): As <0.01, Cd <0.005, Cr6+ <0.05, Cu <0.01, Fe 0.02, Pb <0.01, Hg <0.0005, Zn <0.01
- Pesticides: organic phosphate <0.1 mg/L
- Chlorine (residual): <0.1 mg/L
- Fluorine: <0.1 mg/L
- NH3 un-ionised: <0.03 mg/L
- Nitrate: 0.61 mg/L
- pH: 7.5
- Hardness (as CaCO3): 48.8 mg/L
- Alkalinity (as HCO3-): 45.6 mg/L
- Ca/Mg ratio: not reported
- Conductivity: 121 micro-Siemens/cm
- Intervals of water quality measurement: not reported
OTHER TEST CONDITIONS
- Adjustment of pH: none
- Photoperiod, light intensity: 16 h light and 8 h dark period, 1000 Lux
- Temperature: test tanks kept in a thermo-regulated room (20 +/- 1 °C)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Daphnia with "inhibited movement" (immobilised or showing only minor movements of their appendages) were recorded after 3, 6, 24, and 48 hours of exposure.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: approx. 1.6
- Justification for using less concentrations than requested by guideline: none (5 concentrations used, including 0% and 100% immobilisation)
- Range finding study (RF): two preliminary tests
- Test concentrations in RF (with % affected daphnia): first study: 10 ppm (0%), 30 ppm (0%), 100 ppm (70%), 300 ppm (100%); second study 30 ppm (0%), 50 ppm (5%), 80 ppm (25%),130 ppm (65%), 200 ppm (100%)
- Results used to determine the conditions for the definitive study: all above - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 200 other: ppm (equivalent to mg/L, with d=1 kg/L)
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- measured: 0 hours: 197 ppm (mg/L); 48 hours: 219 ppm (mg/L)
- Basis for effect:
- mobility
- Remarks on result:
- other: no daphnia affected in either study
- Duration:
- 6 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 200 other: ppm (equivalent to mg/L, with d=1 kg/L)
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- measured: 0 hours: 197 ppm (mg/L); 48 hours: 219 ppm (mg/L)
- Basis for effect:
- mobility
- Remarks on result:
- other: 3/30 daphnia affected at 200 ppm in second study
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 182 other: ppm (equivalent to mg/L, with d=1 kg/L)
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- measured (average of all concentrations tested): 0 hours: 100 +/- 4 % of nominal concentration; 48 hours: 106 +/- 6 % of nominal concentration
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% confidence interval: 164 - 202 ppm
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 105 other: ppm (equivalent to mg/L, with d=1 kg/L)
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- measured (average of all concentrations tested): 0 hours: 100 +/- 4 % of nominal concentration; 48 hours: 106 +/- 6 % of nominal concentration
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% confidence interval: 95 - 116 ppm
- Details on results:
- - Behavioural abnormalities: none, except inhibited movement
- Observations on body length and weight: not applicable
- Other biological observations: none reported
- Mortality of control: no immobilisation observed
- Other adverse effects control: none reported
- Abnormal responses: none reported
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no precipitation observed, measured concentration at 0 hours: 100 +/- 4 % of nominal; at 48 hours: 106 +/- 6 % of nominal
- Effect concentrations exceeding solubility of substance in test medium: Although the saturation concentration of the test material has been reported in a fish toxicity study (Tapp & Caunter 1987) to be about 30 mg/L (using acetone as water-miscible solvent), in the present investigation concentrations up to 200 mg/L (300 mg/L in the pretest) were reached and analytically confirmed (by HPLC). Stock solutions were probably prepared using an Ultra-Turrax rotor/stator high-speed dispersing device, which is known to achieve substantial particle size reduction and create stable emulsions. It is possible that such emulsions were formed from the test substance, and representatively sampled from the test tanks. - Results with reference substance (positive control):
- none
- Reported statistics and error estimates:
- No statistics on analytical concentrations performed in the report. Mean concentrations (test tanks 1-3, first and second study) calculated by reviewer: at 0 hours: 100 +/- 4 % of nominal concentration; at 48 hours: 106 +/- 6 % of nominal concentration.
EC50 and 95% confidence limits·at each time of observation calculated by Litchfield-Wilcoxon method, based on nominal concentrations. The 48-hour LC50 values were 98 (84-114) ppm in the first study, and 117 (99-138) in the second. 24- hour values: 165 (138-198) in the first and 200 (138-290) in the second study. These results were considered to be reproducible, because the 95% confidence intervals overlapped. The acute EC50 values and 95% confidence limits were calculated on the basis of the combined data for both studies.
Any other information on results incl. tables
Number and percentage of affected daphnia
Nominal | Tank | 1st study: hours | 1st study: hours | ||||||
conc. ppm | no | 3 | 6 | 24 | 48 | 3 | 6 | 24 | 48 |
0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
control | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
Mean | % of total | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
30 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
Mean | % of total | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% |
50 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | |
3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | |
Mean | % of total | 0.0% | 0.0% | 0.0% | 6.7% | 0.0% | 0.0% | 0.0% | 0.0% |
80 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 2 |
2 | 0 | 0 | 0 | 3 | 0 | 0 | 1 | 2 | |
3 | 0 | 0 | 0 | 5 | 0 | 0 | 1 | 1 | |
Mean | % of total | 0.0% | 0.0% | 0.0% | 33.3% | 0.0% | 0.0% | 6.7% | 16.7% |
130 | 1 | 0 | 0 | 0 | 7 | 0 | 0 | 1 | 5 |
2 | 0 | 0 | 2 | 8 | 0 | 0 | 1 | 6 | |
3 | 0 | 0 | 3 | 7 | 0 | 0 | 2 | 3 | |
Mean | % of total | 0.0% | 0.0% | 16.7% | 73.3% | 0.0% | 0.0% | 13.3% | 46.7% |
200 | 1 | 0 | 0 | 7 | 10 | 0 | 1 | 4 | 10 |
2 | 0 | 0 | 8 | 10 | 0 | 0 | 5 | 9 | |
3 | 0 | 0 | 8 | 10 | 0 | 2 | 6 | 10 | |
Mean | % of total | 0.0% | 0.0% | 76.7% | 100.0% | 0.0% | 10.0% | 50.0% | 96.7% |
Analytically determined concentrations
Analytical concentration ppm | |||||||
Nominal | Tank | 1st study | 2nd study | ||||
conc. ppm | no | 0 hours | 48 hours | Mean, SD | 0 hours | 48 hours | Mean, SD |
0 | 1 | <0.5 | <0.5 | <0.5 | <0.5 | <0.5 | |
control | 2 | <0.5 | <0.5 | <0.5 | <0.5 | ||
3 | <0.5 | <0.5 | <0.5 | <0.5 | |||
30 | 1 | 31 | 33 | 33 | 28 | 32 | 32 |
2 | 31 | 34 | 0.6 | 28 | 33 | 1.0 | |
3 | 31 | 33 | 28 | 31 | |||
50 | 1 | 53 | 53 | 51 | 51 | 45 | 48 |
2 | 53 | 52 | 2.1 | 51 | 49 | 3.1 | |
3 | 53 | 49 | 51 | 51 | |||
80 | 1 | 76 | 83 | 83 | 82 | 84 | 88 |
2 | 76 | 84 | 1.5 | 82 | 87 | 4.6 | |
3 | 76 | 81 | 82 | 93 | |||
130 | 1 | 130 | 135 | 136 | 127 | 145 | 144 |
2 | 130 | 133 | 3.6 | 127 | 148 | 5.1 | |
3 | 130 | 140 | 127 | 138 | |||
200 | 1 | 198 | 226 | 217 | 196 | 218 | 220 |
2 | 198 | 222 | 11.7 | 196 | 242 | 20.6 | |
3 | 198 | 204 | 196 | 201 |
Test water: pH, dissolved oxygen, and temperature
Nominal | Tank | pH | Dissolved oxygen mg/L | Temperature °C | |||||||||
1st study | 2nd study | 1st study | 2nd study | 1st study | 2nd study | ||||||||
concentration | no | 0 h | 48 h | 0 h | 48 h | 0 h | 48 h | 0 h | 48 h | 0 h | 48 h | 0 h | 48 h |
0 ppm | 1 | 7.6 | 7.4 | 7.4 | 7.5 | 8.3 | 7.4 | 8.2 | 7.0 | 20.3 | 19.4 | 19.5 | 19.6 |
(control) | 2 | 7.6 | 7.4 | 7.4 | 7.5 | 8.3 | 7.6 | 8.2 | 6.8 | 20.3 | 19.4 | 19.5 | 19.6 |
3 | 7.6 | 7.4 | 7.4 | 7.5 | 8.3 | 7.7 | 8.2 | 6.7 | 20.3 | 19.4 | 19.5 | 19.6 | |
30 ppm | 1 | 7.6 | 7.4 | 7.6 | 7.3 | 8.1 | 7.8 | 8.3 | 7.0 | 20.3 | 19.4 | 19.5 | 19.6 |
2 | 7.6 | 7.5 | 7.6 | 7.4 | 8.1 | 7.7 | 8.3 | 6.2 | 20.3 | 19.4 | 19.5 | 19.6 | |
3 | 7.6 | 7.4 | 7.6 | 7.4 | 8.1 | 7.7 | 8.3 | 6.4 | 20.3 | 19.4 | 19.5 | 19.6 | |
50 ppm | 1 | 7.6 | 7.3 | 7.6 | 7.5 | 8.0 | 7.1 | 8.3 | 6.9 | 20.3 | 19.4 | 19.5 | 19.6 |
2 | 7.6 | 7.2 | 7.6 | 7.5 | 8.0 | 7.1 | 8.3 | 6.3 | 20.3 | 19.4 | 19.5 | 19.6 | |
3 | 7.6 | 7.2 | 7.6 | 7.5 | 8.0 | 7.2 | 8.3 | 6.5 | 20.3 | 19.4 | 19.5 | 19.6 | |
80 ppm | 1 | 7.6 | 7.1 | 7.6 | 7.4 | 8.1 | 7.4 | 8.1 | 6.9 | 20.3 | 19.4 | 19.5 | 19.6 |
2 | 7.6 | 7.1 | 7.6 | 7.3 | 8.1 | 6.9 | 8.1 | 6.7 | 20.3 | 19.4 | 19.5 | 19.6 | |
3 | 7.6 | 7.0 | 7.6 | 7.4 | 8.1 | 6.6 | 8.1 | 6.9 | 20.3 | 19.4 | 19.5 | 19.6 | |
130 ppm | 1 | 7.5 | 7.0 | 7.5 | 7.3 | 8.4 | 7.5 | 7.8 | 7.1 | 20.3 | 19.4 | 19.5 | 19.6 |
2 | 7.5 | 7.0 | 7.5 | 7.3 | 8.4 | 7.5 | 7.8 | 6.9 | 20.3 | 19.4 | 19.5 | 19.6 | |
3 | 7.5 | 6.9 | 7.5 | 7.3 | 8.4 | 7.0 | 7.8 | 7.0 | 20.3 | 19.4 | 19.5 | 19.6 | |
200 ppm | 1 | 7.4 | 6.6 | 7.3 | 6.9 | 8.4 | 7.0 | 8.2 | 7.0 | 20.3 | 19.4 | 19.5 | 19.6 |
2 | 7.4 | 6.7 | 7.3 | 6.9 | 8.4 | 7.3 | 8.2 | 6.9 | 20.3 | 19.4 | 19.5 | 19.6 | |
3 | 7.4 | 6.4 | 7.3 | 6.9 | 8.4 | 6.6 | 8.2 | 7.2 | 20.3 | 19.4 | 19.5 | 19.6 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The acute EC50 of the test substance to the daphnia (Daphnia pulex) was estimated to be 182 (164 - 202) mg/L at 24 hours and 105 (95 - 116) mg/L at 48 hours of exposure. The study report is relevant, adequate and reliable for risk assessment, classification and labeling.
- Executive summary:
The acute toxicity of the test material was assessed in the daphnia (Daphnia pulex), at five nominal concentrations, 30, 50, 80, 130, and 200 ppm (equivalent to mg/L), in a freshwater static test system. The test substance (500 mg) was mechanically dispersed in 2.5 L water for the top concentration, and further diluted to make up the other test solutions. Concentrations in all tanks were analyzed by HPLC before and after exposure (0 and 48 hours); analytical concentrations averaged 100% +/- 4% of the nominal concentrations at 0 hours, and 106% +/- 6% at the end of exposure. Dissolved oxygen levels always remained >= 6.2 mg/L; pH (6.4 - 7.6) and temperature (19.4 – 20.3 °C) were within the recommendations, whereas water hardness (48.8 mg/L) was lower than the requirement of the guideline issued in 2002 (not part of the 1984 issue). The dose groups comprised 30 first instar daphnia (less than 24 hours old) evenly distributed to 3 tanks (250 ml each) per concentration (for each of the two independent studies). Immobilisation and signs of toxicity were recorded at 3, 6, 24, and 48 hours.
Concentration-dependent immobilisation between 0 and 100% was observed (0% in freshwater controls). A statistical calculation of the concentration inhibiting normal swimming in 50% of the animals (EC50) was performed, and confidence limits (CL) estimated; the reproducibility of the two independent studies was good. The author estimates an EC50 of 182 (CL: 164 - 202) ppm (mg/L) to first instars of Daphnia pulex at 24 hours, and 105 (CL: 95 - 116) ppm at 48 hours, on the combined data of both experiments.
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