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EC number: 270-390-7 | CAS number: 68427-32-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October-November 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited reported study with basic data given comparable to guideline/standard.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Test was carried out before OECD guideline was available
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
Test material
- Reference substance name:
- Decyl dihydrogen phosphate, potassium salt
- EC Number:
- 270-390-7
- EC Name:
- Decyl dihydrogen phosphate, potassium salt
- Cas Number:
- 68427-32-7
- Molecular formula:
- C10H23O4P.xK
- IUPAC Name:
- potassium decyl hydrogen phosphate
- Details on test material:
- Name of test compound: TL 522 45% a.s.
No further info
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CFY
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no info
- Age at study initiation: no info
- Weight at study initiation: 95-120 g
- Fasting period before study: overnight
- Housing: no info
- Diet (e.g. ad libitum): no info
- Water (e.g. ad libitum): no info
- Acclimation period: no info
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no info
- Humidity (%): no info
- Air changes (per hr): no info
- Photoperiod (hrs dark / hrs light): no info
IN-LIFE DATES: October-November 1974
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE: not used
MAXIMUM DOSE VOLUME APPLIED: 6.4 mL/kg bw
DOSAGE PREPARATION (if unusual): no info
- Doses:
- RF test: 0, 0.4, 1.6 and 6.4 mL/kg bw
Main test: 0, 1.0, 1.6, 2.5, 4.0 and 6.4 mL/kg bw - No. of animals per sex per dose:
- RF test: 2 (total of 16 rats)
Main study: 5 (total of 60 rats) - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no info
- Necropsy of survivors performed: yes - Statistics:
- LD50 and 95% confidence intervals were calculated by the method of Weil CS (1952) Biometrics, 8, 249
Results and discussion
- Preliminary study:
- See below
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 - < 5 000 mg/kg bw
- Mortality:
- See data below
Death occurred between two and ten hours after treatment. - Clinical signs:
- other: Signs of reaction to treatment, observed shortly after dosing, includcd lethargy and piloerection. These signs were accompanied by a slight increase in salivation in rats treated at 2.5 ml/kg and above and later by slight ataxia in female rats treated at
- Gross pathology:
- Autopsy of deceased animals revealed slight to moderate haemorrhage of the stomach and small intestines, and slight injection of mesenteric blood vessels. Slight darkening of the liver and kidneys was observed in four rats. In survivors, autopsy findings were normal.
- Other findings:
- None
Any other information on results incl. tables
RF test - mortality M / F
0 ml/kg: 0/2 & 0/2
0.4 ml/kg: 1/2 & 0/2 (25%)
1.6 ml/kg: 0/2 & 0/2
6.4 ml/kg: 2/2 & 2/2 (100%)
Main study: mortality M / F
0 ml/kg: 0/5 & 0/5
1.0 ml/kg: 0/5 & 0/5
1.6 ml/kg: 0/5 & 0/5
2.5 ml/kg: 1/5 & 1/5 (20%)
4.0 ml/kg: 3/5 & 2/5 (50%)
6.4 ml/kg: 3/5 & 5/5 (80%)
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The LD50 value of 4.1 mL/kg in rats of the tested product consisting of 45% a.s. and the specific density of the substance decyldihydrogenphosphate, potassium salt (CAS no 68427-32-7) of 1.44 g/ml as given under section 4.4 in IUCLID, together with the stated concentration of 45%, the LD50 value of decyldihydrogenphosphate, potassium salt (CAS: 68427 -32 -7) will be 2000 - 5000 mg a.i./kg bw.
- Executive summary:
Rats of the CFY strain were starved overnight before treatment with the tested product consisting of 45% decyldihydrogenphosphate, potassium salt (CAS: 68427 -32 -7). The tested product consisting of 45% decyldihydrogenphosphate, potassium salt (CAS: 68427 -32 -7) was administered undiluted, by oral intubation at a dosage volume in the full scale test of 1.0 to 6.4 ml/kg bodyweight. Rats treated with water alone (6.4 ml/kg ) served as controls.
During the observation period of 14 days, a record was kept of all mortalities and signs of toxicity. Signs of reaction to treatment, observed shortly after dosing, included lethargy and piloerection. These signs were accompanied by a slight increase in salivation in rats treated at 2.5 ml/kg and above and later by slight ataxia in female rats treated at 2.5 ml/kg and all rats at 4.0 and 6.4 ml/kg. Death occurred between two and ten hours after treatment. Autopsy revealed slight to moderate haemorrhage of the stomach and small intestines, and slight injection of mesenteric blood vessels. Slight darkening of the liver and kidneys was observed in four rats. Recovery of survivors, as judged by external appearance and behaviour, was apparently complete within 5 days of treatment. This observation was substantiated by normal bodyweight gains compared with controls, and normal autopsy findings. The acute median lethal oral dose (LD50) and its 95% confidence limits to rats of of the tested product consisting of 45% decyldihydrogenphosphate, potassium salt (CAS: 68427 -32 -7) were calculated to be: 4.1 (3.1 to 5.5) ml/kg bodyweight.
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