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EC number: 279-459-6 | CAS number: 80410-33-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Aug - Sep 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Before treatment the entire back and the flank of the rabbits were shaved with an electric clipper and immediately before treatment the shaven skin on one side was slightly scarified with the help of a "Schröpfschnäpper", Aesculap, Switzerland. Gauze patches of 2.5 x 2.5 cm with 0.5 g of the test material were applied to the prepared abraded and intact skin. The patches were covered with an impermeable material and were fastened to the body of the rabbit with adhesive tape. The dressings were removed after a 24 hour application. The skin reaction was appraised upon removal and during an observation period of 7 days.
- GLP compliance:
- no
- Remarks:
- pre-GLP study
Test material
- Reference substance name:
- Tris[2-[[2,4,8,10-tetra-tert-butyldibenzo[d,f][1,3,2]dioxaphosphepin-6-yl]oxy]ethyl]amine
- EC Number:
- 279-459-6
- EC Name:
- Tris[2-[[2,4,8,10-tetra-tert-butyldibenzo[d,f][1,3,2]dioxaphosphepin-6-yl]oxy]ethyl]amine
- Cas Number:
- 80410-33-9
- Molecular formula:
- C90H132NO9P3
- IUPAC Name:
- 2-[(2,4,8,10-tetra-tert-butyldibenzo[d,f][1,3,2]dioxaphosphepin-6-yl)oxy]-N,N-bis{2-[(2,4,8,10-tetra-tert-butyldibenzo[d,f][1,3,2]dioxaphosphepin-6-yl)oxy]ethyl}ethanamine
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: CIBA-GEIGY Limited
- Weight at study initiation: 2 - 3 kg
- Housing: individually
- Diet: standard rabbit food (NAFAG, No. 814, Gossau SG); ad libitum
- Water: ad libitum
- Acclimation period: minimum of 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 55 ± 10
- Photoperiod (hrs dark / hrs light): 12 / 12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: polyethylene glycol (PEG 400) + saline (70:30 parts)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
- Concentration (if solution): 50%
VEHICLE
- Concentration (if solution): polyethylene glycol (PEG 400) + saline (70:30 parts) - Duration of treatment / exposure:
- 24 h
- Observation period:
- 7 days
- Number of animals:
- 3 males and 3 females
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Type of wrap if used: gauze patches, covered with an impermeable material
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24 h
OBSERVATION TIME POINTS
upon removal and during an observation period of 7 days
SCORING SYSTEM:
Erythema and eschar formation:
No erythema.....................................................0
Very slight erythema (barely perceptible)........1
Well defined erythema......................................2
Moderate to severe erythema..........................3
Severe erythema (beet redness) to slight eschar formation (injuries in depth)....................4
Total possible erythema score 4
Edema formation:
No edema.................0
Very slight edema (barely perceptible)............................................1
Slight edema (edges of area well defined by definite raising).........2
Moderate edema (raised approximately 1 mm).................................3
Severe edema (raised more than 1 mm and extending beyond area of exposure).............4
Total possible edema score 4
Assessment of irritation:
0
0.1-1.0 = minimal
1.1-2.0 = slight
2.1-4.0 = moderate
4.1-6.0 = marked
6.1-8.0 = extreme
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- other: 24/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- The test substance was found to cause a minimal irritation when applied to abraded rabbit skin.
There were no irritating effects when the test substance was applied to intact skin. - Other effects:
- No signs of systemic intoxication were observed throughout the whole test period.
Any other information on results incl. tables
Table 1: Calculation of the primary skin irritation index
|
MEAN REACTION SCORE |
|
|||||||||
Time after exposure hours |
eryth e ma |
edema |
|||||||||
|
|
|
|
||||||||
intact skin |
abraded skin |
intact skin |
abraded skin |
||||||||
24 |
0 |
0.3 |
0 |
0 |
|||||||
72 |
0 |
0.2 |
0 |
0 |
|||||||
|
|
|
|
|
|||||||
total |
0 |
+ |
0.5 |
+0 |
+ |
0 |
= |
0.5 |
primary irritation index = 0.5 : 4 = 0.1
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions of the present experiment the test substance was found to cause a minimal irritation when applied to abraded rabbit skin.
The calculated primary irritation index was 0.1.
There were no irritating effects when the test substance was applied to intact skin.
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