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Diss Factsheets
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EC number: 262-309-9 | CAS number: 60580-61-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- not specified
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Deviations from the OECD guideline 402 (1981): number of animals was too low; 4 animals were apparently used during the study, but only 2 animals were mentioned in the results; size of patch area was not reported; applied dose was not clearly stated; observations period lasted 8 days only; exposure period was 20 hours at a maximum instead of 24 hours; clinical observations were not made daily; body weight measurements and gross pathology were not conducted; housing conditions were missing; hair removal was not described
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- not specified
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981-05-12
- Deviations:
- yes
- Remarks:
- no detailed description of test performance, size of dermal application area are not described, exposure time too long (20 hours), scoring after 24 hours and 8 days only, no Draize scale was used
- GLP compliance:
- no
- Remarks:
- not mandatory at the time of study conduct
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M. Gaukler, Offenbach, Germany
- Weight (mean): 3.0 kg
- Diet (ad libitum): ssniff K-Standarddiät für Kaninchen (INTERMAST GmbH, Soest, Germany)
- Water: ad libitum - Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Concentration: 2 g of a 50% aqueous solution (equivalent to 1 g of pure substance) - Duration of treatment / exposure:
- 1 min, 5 min, 15 min and 20 hours
- Observation period:
- 8 days
- Number of animals:
- 4 (in the results, only 2 animals are listed)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): after 1, 5 and 15 minutes appplication the treated skins were first cleaned with undiluted lutrol and then with 50% aqueous solution of lutrol. After 20 hours of exposure, the skin was not cleaned.
OBSERVATION TIME POINTS
- at 24 hours and 8 days after application
SCORING SYSTEM:
- Method of calculation: no Draize scale was used
EXAMINATIONS performed:
- local irritant effects and clinical signs - Remarks on result:
- other: After 24 hours 2 animals showed a questionable overlapping redness on the back following 20 hours exposure time. No more irritant effects were observed. Full reversibility of effects after 8 days.
- Irritant / corrosive response data:
- After 24 hours 2 animals showed a questionable overlapping redness on the back following 20 hours exposure time.
No more irritant effects were observed. Full reversibility of effects after 8 days.
The other two animals are not listed. - Other effects:
- No clinical signs were observed.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on this vivo study (OECD 404), the substance is not irritating to the skin.
According to Regulation (EC) No 1272/2008 and subsequent adaptations, the substance does not require classification as skin irritant.
EAR:
After 24 hours 2 animals showed a questionable redness on the ear for 20 hours exposure time. Full reversibility of effects after 8 days.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 1981-05-12
- Deviations:
- yes
- Remarks:
- please refer to the field "Rationale for reliability incl. deficiencies" above
- GLP compliance:
- no
- Remarks:
- not mandatory at the time of study conduct
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- liquid - solid: mixture of
- Details on test material:
- 50% aqueous suspension of zinc 5-nitroisophthalate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M. Gaukler, Offenbach, Germany
- Weight (mean): 3.0 kg
- Diet (ad libitum): ssniff K-Standarddiät für Kaninchen (INTERMAST GmbH, Soest, Germany)
- Water: ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: the product was applied as a 50 % aqueous solution onto the skin of the back and the ear of the rabbits.
Back: a patch with the test substance solution was applied to the skin under occlusive dressing.
Ear: a cotton patch with the test substance solution was applied to the skin and fix with a gauze bandage.
REMOVAL OF TEST SUBSTANCE
- Washing: the treated skin was washed with undiluted Lutrol 9 followed by washing with a 50% aqueous Lutrol solution. Following the 20 hour exposure, the skin was not cleaned.
TEST MATERIAL
- Concentration: 2 g of a 50% aqueous solution (equivalent to 1 g of pure substance) - Duration of exposure:
- Back: 1, 5, and 15 minutes as well as 20 hours
Ear: 20 hours - Doses:
- 2 g of a 50% aqueous solution (equivalent to 1 g of pure substance)
- No. of animals per sex per dose:
- 4 rabbits (NOTE: 2 animals were only stated in the result section)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 24 hours and 8 days after application observations were recorded
Observations for local irritation and clinical signs were made. - Statistics:
- not applicable
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- not specified
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed during the study. The findings collected during an 8-day observation period revealed a slight temporary irritant effect only after 20 hours of exposure. No further clinical signs were observed.
- Mortality:
- No mortality was observed during the study (it is assumed based on the results for clinical signs that no mortality occurred even 2/4 animals were not mentioned in the results).
- Clinical signs:
- NOTE: 2/4 animals were not mentioned in the results. Results were only mentioned for 2 animals)
Back:
24 hours after application: 2 animals showed a questionable overlapping redness on the back following the 20 hour exposure period.
8 days after application: no irritating effects were observed
Ear:
24 hours after application: redness was observed in two animals following the 20 hour exposure period.
8 days following application: no irritating effects were observed.
No futher clinical signs were observed. - Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- No mortality was observed during the study. The findings collected during an 8-day observation period revealed a slight temporary irritant effect only after 20 hours of exposure. No further clinical signs were observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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