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Diss Factsheets
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EC number: 947-892-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- No positive control tested
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP regulations
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Study performed before the LLNA guidelines were published.
Test material
- Reference substance name:
- Aluminum, hydroxy[29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, chloro sulfo derivs., sodium salts
- EC Number:
- 307-259-1
- EC Name:
- Aluminum, hydroxy[29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, chloro sulfo derivs., sodium salts
- Cas Number:
- 97592-62-6
- Molecular formula:
- not available
- IUPAC Name:
- Aluminum, hydroxy[29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, chloro sulfo derivs., sodium salts
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Name used in the study report: FAT 60'149/B
- Batch number: Partie 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Pirbright white
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Ivanovas, Germany
- Age at study initiation: approximately 10 weeks
- Weight at study initiation: 300-400 g
- Housing: individually in Macrolon cages (type 3)
- Diet: ad libitum standard guinea pig pellets - NAFAG No. 830, Gossau SG, supplemented with fresh carrots
- Water: ad libitum
- Acclimation period: 12 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 1
- Humidity (%): 50 ± 5
- Photoperiod (hrs dark / hrs light): 10/14
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal and epicutaneous
- Vehicle:
- other: intradermal: saline, and adjuvant and saline; epicutaneous: vaseline phH VI
- Concentration / amount:
- - intradermal application: 0.1% ; 0.1 mL per injection
- epicutaneous application: 30% - Day(s)/duration:
- 7 days after the intradermal application, the substance was applied epicutaneous for 48 hours.
- Adequacy of induction:
- other: The concentrations of the test compound for the induction and challenge periods were determined on separate animals before starting the test procedure.
Challenge
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: soft white paraffin
- Concentration / amount:
- 30%
- Day(s)/duration:
- 24 hours
- Adequacy of challenge:
- other: The concentrations of the test compound for the induction and challenge periods were determined on separate animals before starting the test procedure.
- No. of animals per dose:
- 20
- Details on study design:
- Test procedure
The concentrations of the test compound for the induction and challenge periods were determined on separate animals before starting the test procedure. A control group was treated with the vehicles alone (negative control).
INDUCTION, INTRADERMAL:
Two intradermal injections (0.1 ml per injection) were made into the nape of the guinea pigs with a mixture of adjuvant and saline, with the test compound in saline and with the test compound in the adjuvant saline mixture.
INDUCTION, EPIDERMAL:
One week later the test substance was incorporated in soft white paraffine and applied on a filterpaper patch to the nape of the animals (occlusive administration for 48 hours). Twenty-four hours before the compound application the induction site was treated epidermal open with 10 % sodium lauryl sulphate in vaseline.
CHALLENGE:
Two weeks after the epidermal induction application the animals were tested on one flank with 30 % FAT 60'149/B in soft white paraffine (24 h occlusive application). Twenty-four hours after removing the dressings the challenge reactions were graded according the Draize scoring scale. The application sites were chemically depilated 3 hours before examination (Veet , 5 minutes). - Challenge controls:
- A control group was treated with the vehicles alone (negative control).
- Positive control substance(s):
- no
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 30%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 30%
- No. with + reactions:
- 0
- Total no. in group:
- 20
Any other information on results incl. tables
None of the animals of the test or control group reacted after epidermal occlusive challenge application.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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