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Diss Factsheets
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EC number: 916-807-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- phototoxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A 2 % dilution of the test substance in absolute ethanol was examined for phototoxic properties in six albino rabbits. A 1/128 % solution of 8-methoxypsoralen in absolute alcohol served as positive control. Amounts of 0.1 mL of the test and control dilution were brought into contact with separated skin areas. Subsequently, the treated skin areas were irradiated with UV-light for 60 minutes. 0.1 mL of the test and of the control dilution were brought into contact with separated skin areas, but left unirradiated.
- GLP compliance:
- yes
- Type of method:
- in vivo
- Endpoint addressed:
- skin irritation / corrosion
Test material
- Reference substance name:
- Reaction mass of 1,2,3,4,5,6,7,8-octahydro-5,5-dimethylnaphthalene-2-carbaldehyde and 1,2,3,4,5,6,7,8-octahydro-8,8-dimethyl-2-naphthaldehyde
- EC Number:
- 916-807-4
- Molecular formula:
- C13H20O
- IUPAC Name:
- Reaction mass of 1,2,3,4,5,6,7,8-octahydro-5,5-dimethylnaphthalene-2-carbaldehyde and 1,2,3,4,5,6,7,8-octahydro-8,8-dimethyl-2-naphthaldehyde
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Description: clear, transparant liquid
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: ENKI-Konijnenfarm, Someren, the Netherlands
- Weight at study initiation: 2500-3500 g
- Housing: Individually in suspended, galvanized cages, fitted with wire-mesh floor and front
- Diet: Standard laboratory rabbit diet, ad libitum
- Water: Tap water, ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18±3
- Humidity (%): 40-70
- Air changes (per hr): ca. 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- ethanol
- Analytical verification of doses or concentrations:
- no
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- One day prior to the start of the experiment, the hair was removed from the back and flanks of the animals using electric clippers in a way as to avoid abrasions. The test was carried out with a 2 % dilution of the test material in absolute ethanol. A 1/128 % solution of 8-methoxypsoralen in absolute ethanol served as a positive control. Amounts of 0.1 mL of the test and control dilution were brought into contact with separated skin areas left of the midline of the back. Subsequently, the treated skin areas were irradiated with UV-light (wavelength about 365 nm) for 60 minutes holding the light source (Philips TL 40 W/ 08) 8 inches from the skin. After removal of the light source 0.1 mL of the test and of the control dilution were brought into contact with separated skin areas right of the midline of the back, in the same sequence as, and opposite to, the treated and irradiated application sites on the left.
Examinations
- Examinations:
- Resulting skin reactions were evaluated by the method of Draize (J. Pharmacol. Exp. Ther. 82 (1944) 377-90) at 24, 48, 72 and 96 hours after application.
- Positive control:
- A 1/128 % solution of 8-methoxypsoralen in absolute ethanol
Results and discussion
- Details on results:
- The 8-MOP solution did not cause any irritation if the treated skin was not UV-irradiated. However, moderate to severe skin irritation occurred in all (six) rabbits after UV-irradiation of the sites treated with the 8-MOP solution. The dermal effects observed generally consisted of well-defined erythema, very slight or slight ischemic necrosis and very slight or slight oedema. The 2 % dilution of the test material caused very slight erythema in one out of six rabbits at the 24 hour time point if the treated skin was not UV-irradiated. Very slight erythema occurred in two out of six rabbits after UV-irradiation of the sites treated with the test substance dilution. The very slight erythema was absent within 48 and 72 hours, respectively. The difference between the numbers of animals showing skin reactions after treatment with the 2 % test item dilution, with and without subsequent UV-irradiation, was considered a chance effect and not of any toxicological significance. On the basis of the present results it is concluded that a 2 % dilution of the test substance in absolute ethanol is not phototoxic for rabbits.
Applicant's summary and conclusion
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