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EC number: 282-025-9 | CAS number: 84082-79-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Salvia officinalis, Labiatae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Forty male albino rats Wistar strain, 10 per group, were fasted for a minimum of 16 hours prior to administration of the test material. The drug was administered as a concentrate.
- GLP compliance:
- no
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Sage, Salvia officinalis, ext.
- EC Number:
- 282-025-9
- EC Name:
- Sage, Salvia officinalis, ext.
- Cas Number:
- 84082-79-1
- IUPAC Name:
- Sage, Salvia officinalis, ext.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200-250 g
- Fasting period before study: 16 hours
- Diet: ad libitum
- Water : ad libitum
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The drug was administered as a concentrate
- Doses:
- 1.29 g/kg bw
2.02 g/kg bw
3.20 g/kg bw
5.00 g/kg bw - No. of animals per sex per dose:
- 10 per group
- Details on study design:
- Observations for mortality were made at 1 and 6 hours after dosing and daily thereafter for fourteen days. Gross necropsies were performed on all survivors.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 600 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At the dose of 1.29 g/kg bw, one animal died
At the dose of 2.02 g/kg bw, four animals died
At the dose of 3.20 g/kg bw, seven animals died
At the dose of 5.00 g/kg bw, nine animals died - Clinical signs:
- The rats experienced lethargy.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The LD50 calculated from the data is 2 600 mg/kg bw with 95% confidence limites of 1 900 and 3300 mg/kg bw.
- Executive summary:
Forty male albino rats Wistar strain, 10 per group, were fasted for a minimum of 16 hours prior to administration of the test material. The drug was administered as a concentrate. Observations for mortality were made at 1 and 6 hours after dosing and daily thereafter for fourteen days. Gross necropsies were performed on all survivors. The rats experienced lethargy. Deaths occured overnight following adnimistration of the drug. The LD50 calculated from the data is 2 600 mg/kg bw with 95% confidence limites of 1 900 and 3300 mg/kg bw.
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