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Diss Factsheets
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EC number: 214-780-7 | CAS number: 1193-81-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- January 1976
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Results difficult to assess due to methodological deficiencies.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Only 1 or 2 animals per dosing level were used (instead of 5)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-cyclohexylethanol
- EC Number:
- 214-780-7
- EC Name:
- 1-cyclohexylethanol
- Cas Number:
- 1193-81-3
- Molecular formula:
- C8H16O
- IUPAC Name:
- 1-cyclohexylethanol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males: 1.8 - 2.1 kg; females: 1.8 - 1.9 kg
- No information on environmental conditions were provided.
IN-LIFE DATES: not indicated
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 794, 1000, 2000 and 3160 mg/kg bodyweight
- No. of animals per sex per dose:
- 794 mg/kg bw: 1 female
1000 mg/kg bw: 1 male and 1 female
2000 mg/kg bw: 1 female
3160 mg/kg bw: 1 male - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not indicated
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 794 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Due to the limited number of animals tested, no correct LD50 can be derived.
- Mortality:
- 794 mg/kg bw: only 1 female animal exposed, no death occurred;
1000 mg/kg bw: 2 animals (1 male and 1 female) were exposed from which 1 male animal died at day 6.
2000 mg/kg bw: only 1 female exposed which died at day 2.
3160 mg/kg bw: only 1 male exposed which died at day 1. - Clinical signs:
- other: Reduced appetite and activity (two to four days in survivors), increasing weakness and collapsing were observed.
- Gross pathology:
- In animals who died during the study lung, liver and kidney hyperemia, slightly enlarged gall bladder, darkened spleen and gastrointestinal inflammation were observed. In animals who were sacrificed after the 14 day observation period, viscera appeared normal.
Applicant's summary and conclusion
- Interpretation of results:
- other: EU CLP classification: Acute Dermal Toxicity Category 4: Harmful in contact with skin.
- Remarks:
- Though no correct LD50 can be drived, dermal toxicity is observed pointing towards EU CLP classification.
- Conclusions:
- Due to the limited number of animals tested (only one or two per dose), no correct LD50 can be derived. However, despite the limitations of the study it can be seen that the acute dermal toxicity (LD50) of the substance is very likely between 794 and 2000 mg/kg bw.
- Executive summary:
In this study performed somewhat equivalent to OECD TG 402 guideline, 5 rabbits (2 males and 3 females) were exposed to the substance. Only 1 or 2 animals per dose were used at dose levels of 794, 1000, 2000 and 3160 mg/kg bw. At the lowest dose, no mortality was seen, at 1000 mg/kg bw one out of two animals died (in six days), at the two highest dose levels both animals died (in two days and one day, resp.). Reduced appetite and activity (two to four days in survivors), increasing weakness and collapsing were observed. In animals that died during the study lung, liver and kidney hyperemia, slightly enlarged gall bladder, darkened spleen and gastrointestinal inflammation were observed. Animals, which were sacrificed after the 14 day observation period, the viscera appeared normal. Due to the limited number of animals tested, no correct LD50 can be derived. However, despite the limitiations in study design it can be seen that the LD50 is very likely between 794 and 2000 mg/kg bw.
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