Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Refer to the analogue approach justification provided in IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Duration:
48 h
Dose descriptor:
EL50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
WAF
Basis for effect:
mobility
Remarks on result:
other:
Remarks:
Source: RA-A, CAS 3234-85-3, Evonik, 2012, D. magna, 48 h
Duration:
48 h
Dose descriptor:
EL50
Effect conc.:
> 0.128 µg/L
Nominal / measured:
meas. (geom. mean)
Conc. based on:
test mat.
Remarks:
WAF
Basis for effect:
mobility
Remarks on result:
other:
Remarks:
Source: RA-A, CAS 3234-85-3, Evonik, 2012, D. magna, 48 h
Conclusions:
The key value retained for the short-term toxicity of the target substance to aquatic invertebrates is an EL50 (48 h) of > 100 mg/L (nominal) and of > 0.128 µg/L (meas. geom. mean), respectively, based on the available experimental study for a structurally and chemically closely related source substance (OECD 202, D. magna); read-across

Description of key information

No toxic effects up to the limit of water solubility (OECD 202, D. magna); read-across

Key value for chemical safety assessment

Additional information

There is no study available, in which the short-term toxicity of the target substance lauryl laurate (CAS 13945-76-1) to aquatic invertebrates was investigated.Therefore, read-across to the structurally related sourcesubstancetetradecyl myristate (CAS 3234-85-3)was conductedin accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. The source substance is characterized by similar fatty acid and alcohol components and is therefore considered a suitable representative for the assessment of the toxicity of the target substance to aquatic invertebrates. A detailed justification of the analogue approach is provided in IUCLID section 13.

The available study with the source substance was conducted according to OECD guideline 202 and GLP. In a static limit test, Daphnia magna was exposed to a water accommodated fraction with a nominal loading rate of 100 mg/L test item for 48 h. GC/EI-MS analysis resulted in a measured geometric mean concentration of 0.128 µg/L.

After 48 h, no immobilization was recorded, resulting in an EL50 of > 0.128 µg/L (measured, geometric mean) and > 100 mg/L (nominal), respectively. Thus it can be concluded that no toxicological effects on aquatic invertebrates are expected up to the limit of water solubility for tetradecyl myristate.

 

Based on the structural and chemical similarity of the target and source substances, the target substance is expected to exhibit a similar ecotoxicological profile as the selected source substance. Therefore, it can be concluded that the target substance lauryl laurate (CAS 13945-76-1) does not cause short-term toxicological effects to aquatic invertebrates up to the limit of water solubility.