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EC number: 216-835-0 | CAS number: 1678-91-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992-01-28 - 1992-04-07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Ethylcyclohexane
- EC Number:
- 216-835-0
- EC Name:
- Ethylcyclohexane
- Cas Number:
- 1678-91-7
- Molecular formula:
- C8H16
- IUPAC Name:
- ethylcyclohexane
- Test material form:
- liquid: volatile
Constituent 1
- Specific details on test material used for the study:
- SRLD or Lot I.D. Number: 7482-9A
Physical State and Appearance: Colorless liquid
Test animals
- Species:
- rat
- Strain:
- other: CD(SD)BR VAF/PlusT
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Body Weight Range at Dosing (grams): Males = 230 - 254 Females =190 - 202
Housing:
All animals were individually housed in suspended, stainless-steel, mesh cages.
Environmental Conditions:
A photoperiod of 12 hours light from 6 a.m. to 6 p.m. Room temperature was maintained at
71-75*F. Relative humidity was maintained at 45-48%.
Diet and-Water:
ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The hair was removed from an area of the dorsal skin with an electric clipper. A single dose of the material was placed in contact with the skin using a fiber pad and an occlusive wrap to hold the test material in place for 24 hours. At the end of the exposure period, the test material was removed with running water.
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 of each sex per dose group
- Control animals:
- no
- Details on study design:
- Clinical Observations:
Animals were observed during the exposure period (Day 0) and once each workday thereafter for the duration of the experiment (a total of 14 calendar days). Observation included, but was not limited to: examination of the hair, skin, eyes, motor activity, feces, and urine. Animals were checked for mortality on weekend days.
Body Weight Determinations:
Body weights were collected on the day of dosing and one and two weeks after dosing.
Necropsy:
All animals were necropsied at the completion of the 14-day observation period.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: No treatment-related abnormal clinical signs were evident at any time during the 14-day observation period.
- Gross pathology:
- No treatment-related changes or signs of organ toxicity were evident at necropsy. In the absence of significant gross organ lesions, no tissue was
collected for histological examination.
Any other information on results incl. tables
Summary Table
DOSE (mg/kg) |
NUMBER OF RATS DOSED (M,F) |
NUMBER OF DEATHS (M,F) |
TIME OF DEATH |
WEIGHT GAIN* (M,F) |
|
1WEEK |
2WEEKS |
||||
2000 |
5,5 |
0,0 |
-------- |
5 +, 5+ |
5 +, 5+ |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal LD50 for this test material was greater than 2000 mg/kg for both sexes.
- Executive summary:
A limit dose of 2000 mg/kg was applied to the skin after the hair was removed with an electric clipper. An occlusive wrap was used to hold the test material against the skin for a period of 24 hours, and at the end of exposure, residual test material was washed off with running water.
No treatment-related abnormal clinical signs were evident at any time during the 14-day observation period. On the last day of the observation period, a small wound with a scab was noted on the shoulder of a single male (Rat 745). Since this animal had appeared clinically normal from the day of dosing to Day 13, this wound was not considered related to administration of the test material. No treatment-related changes or signs of organ toxicity were evident at necropsy. In the absence of significant gross organ lesions, no tissue was collected for histological examination. Based on weight gain and survival rate, there was no evidence of percutaneous absorption. The acute dermal LD50 for this test material was greater than 2000 mg/kg for both sexes.
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