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EC number: 816-285-7 | CAS number: 1263133-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- ISO 11268-1 (Effects of Pollutants on Earthworms. 1. Determination of Acute Toxicity Using Artificial Soil Substrate)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- yes
- Remarks:
- Quartz sand
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- yes
- Total exposure duration:
- 14 d
- Test temperature:
- 18.0 to 22.0°C
- pH:
- Test initiation: 7.52 to 7.59
Test termination: 7.20 to 7.27 - Moisture:
- Initiation: 24.82 to 25.85% (equivalent to 57.49 to 59.88% of the total water holding capacity)
Termination: 24.09 to 26.13% (equivalent to 55.80 to 60.53% of the total water holding capacity) - Nominal and measured concentrations:
- 0, 62.5, 125, 250, 500 and 1000 mg/kg dry soil
- Reference substance (positive control):
- yes
- Remarks:
- 2-Chloroacetamide (tested twice per year)
- Key result
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Highest dose tested
- Key result
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- < 62.5 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: biomass
- Key result
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Highest dose tested
- Validity criteria fulfilled:
- yes
- Conclusions:
- 7 d and 14 d LC50 (Eisenia fetida): >1000 mg/kg dry soil (mortality)
14 d NOEC (Eisenia fetida): <62.5 mg/kg dry soil (biomass)
14 d NOEC (Eisenia fetida): 1000 mg/kg dry soil (mortality) - Executive summary:
The acute toxicity of the test substance to the earthworm, Eisenia fetida (Savigny), was estimated in a 14-day soil exposure laboratory study conducted as per OECD Guideline 207 and ISO-Guideline 11268-1. Four replicates of ten clitellated adult earthworms were each exposed to nominal concentrations of 62.5, 125, 250, 500 and 1000 mg/kg dry soil. The untreated control (Quartz sand) was replicated four times, with ten earthworms in each replicate.
The toxic reference, 2-Chloroacetamide, is tested twice a year. The 14-day LC50 of the most recent test was 30.8 mg Chloroacetamide/kg dry soil.
Earthworms were assessed for mortality and behavioral effects after 7 and 14 days of exposure and earthworm body weights were assessed at day 0 and day 14.
According to the results of this study, the 7-day and the 14-day LC50 of the test substance was determined to be greater than 1000 mg/kg dry soil. The 14-day No-Observed-Effect Concentration (NOEC) with respect to biomass and mortality was determined to be less than 62.5 mg and 1000 mg/kg dry soil, respectively.
Reference
Description of key information
14 -day EC50 (earthworm) > 1000 mg/kg; OECD ; Reliability = 1
14-day NOEC ( Eisenia fetida, earthworm) > 1000 mg/kg (mortality); OECD 207; Reliability = 1
14-day NOEC ( Eisenia fetida, earthworm) < 62.5 mg/kg (biomass); OECD 207; Reliability = 1
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 1 000 mg/kg soil dw
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 62.5 mg/kg soil dw
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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