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EC number: 216-322-1 | CAS number: 1559-34-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- 1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The source substance triethylene glycol butyl ether (TEGBE) is adjacent to the target substance TetraEGBE in the E series butyl glycol ether homologous series. Based on a reliable QSAR (ECOSAR) for other aquatic toxicity end points, the toxicity to aquatic species is expected to decrease with increasing molecular weight of the homologous series, using TEGBE as a surrogate to estimate the toxicity of TetraEGBE should be conservative approach.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source: Triethylene glycol butyl ether
Target: Ttetraethylene glycol butyl ether.
Impurities: Both the source and target substances will contain the same impurities as they are produced in the same process, therefore they will have similar impurity profiles and impurities will not impact on the validity of the read across. Indeed both would contain the other as an impurity.
3. ANALOGUE APPROACH JUSTIFICATION
See hypothesis above. TEGBE is expected to be more toxic than TetraEGBE therefore using data from studies using pure TEGBE to estimate the toxicity of TetraEGBE will be a conservative approach
4. DATA MATRIX
QSAR information below shows how toxicity increases with decreasing molecular weight for the other aquatic toxicity end points. The same trend is expected with micro-organisms (mode of action is non specific narcosis) therefore using TEGBE data directly should be conservative.
TEGBE TetraEGBE
Fish LC50 (g/L) 10 22
Daphnia EC50 (g/L 4.8 10
Algae EC50 (g/L) 1.7 3.2
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Very basic information only available. Likely to be sufficiently reliable only when used in a weight of evidence approach.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- According to the test method published in: Alsop et al., "Bacterial Growth Inhibition Tests", J. Water Pollution Control Federation, Vol 52: No. 10, October, 1980.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- activated sludge
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 16 h
- Duration:
- 16 h
- Dose descriptor:
- IC50
- Effect conc.:
- > 5 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Validity criteria fulfilled:
- not specified
- Executive summary:
In a bacterial growth inhibition study using sewage micro-organisms for which only basic details are available, the IC50 was found to be greater than 5000mg/l.
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- not specified
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- activated sludge, industrial
- Details on inoculum:
- - Activated sludge from the BASF wastewater treatment plant
- Final dry solids concentration: 1 g/L - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 30 min
- Details on test conditions:
- Nominal test concentrations: 1.5, 300, 1995 mg/L
- Reference substance (positive control):
- not specified
- Duration:
- 30 min
- Dose descriptor:
- EC10
- Effect conc.:
- > 1 995 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Details on results:
- - No inhibition of respiration was observed up to a concentration of 1995 mg/L.
- The test substance caused an increased bacterial ceIl multiplication in the concentration range of 300 - 1995 mg/L (max. 88 % compared to the control). - Executive summary:
In a guideline activated sludge respiration inhibition test using 2-(2-(2-butoxyethoxy)ethoxy)ethanol, no effects were observed up to the maximum tested concentration of 1995mg/l.
Data source
Materials and methods
Test material
- Reference substance name:
- 3,6,9,12-tetraoxahexadecan-1-ol
- EC Number:
- 216-322-1
- EC Name:
- 3,6,9,12-tetraoxahexadecan-1-ol
- Cas Number:
- 1559-34-8
- Molecular formula:
- C12H26O5
- IUPAC Name:
- 3,6,9,12-tetraoxahexadecan-1-ol
- Test material form:
- liquid
Constituent 1
Results and discussion
Effect concentrations
- Duration:
- 30 min
- Dose descriptor:
- EC10
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks on result:
- other: not determinable due to no adverse effects being seen at maximum tested dose of 1995 mg/L
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.