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EC number: 907-237-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 May 2017 - 04 May 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 22 January 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 30 May 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil
- Radiolabelling:
- no
- Test temperature:
- 30 ºC
- Details on study design: HPLC method:
- EQUIPMENT
- Instrument: Agilent Technologies 1100 series, incorporating autosampler and workstation
- Column: Waters HSS Cyano 5μm (150 x 4.6 mm id)
- Column temperature: 30 ºC
- Flow: 1.0 mL/min
- Injection volume: 10 µL
- UV detection: 210 nm
MOBILE PHASE
- Type: methanol: water (55:45 v/v)
- pH: 6.2
- Solutes for dissolving reference substances were prepared in methanol
DETERMINATION OF DEAD TIME
Method: determined by measuring the retention time of formamide (purity 99.94%, 678 solution in mobile phase).
REFERENCE SUBSTANCES
- Solutions of reference items were prepared in methanol.
- Identity: Acetanilide, Atrazine, Isoproturon, Triadimenol, Linuron, Naphthalene, Endosulfan-diol, Fenthion, α-Endosulfan, Phenanthrene, Diclofop-methyl and DDT
PREPARATION OF TEST SOLUTIONS
- Test item (0.5007 g) was diluted to 100 mL with acetonitrile to give a concentration of 5.01 x 103 mg/L.
- The sample solution matrix blank was acetonitrile
REPETITIONS
- Number of determinations: 2 (for reference substances, test solutions and blank solution)
EVALUATION
- Calculation of capacity factors k': k'= (tr-t0)/t0 where tr = retention time, t0 = mean column dead time
- Determination of the log Koc value: via linear regression; log k' = 0.3059 x log Koc - 0.6283 (r = 0.944) - Key result
- Type:
- log Koc
- Value:
- >= 1.58 - <= 4.25 dimensionless
- pH:
- 6.2
- Temp.:
- 30 °C
- Key result
- Sample No.:
- #4
- Type:
- log Koc
- Value:
- 3.32 dimensionless
- pH:
- 6.2
- Temp.:
- 30 °C
- Remarks on result:
- other: main constituent (84%)
- Details on results (HPLC method):
- In the absence of any relevant dissociating functional groups, no specific manipulation of the mobile phase pH was necessary to achieve an unionized form of the test item. Therefore the determination was performed at an unadjusted, approximately neutral pH.
- Retention times of reference substances used for calibration: see table enclosed
- Details of fitted regression line (log k' vs. log Koc): y = 0.3059 x -0.6283 (r2=0.944, n=12)
- Graph of regression line attached
- The chromatogram of the test substance showed 7 substance peaks.
- Average retention data for test substance: see table below
- The value of log10 Koc obtained from duplicate measurements was within ± 0.01 log units. - Conclusions:
- Based on the HPLC estimation method at pH = 6.2 using soil-adsorption reference data, the log Koc for Intreleven aldehyde was determined to be in the range of 38.3 to 1.77 x 10^4, log10 Koc 1.58 to 4.25. The main constituent detected, contributing 84% of the total area by percentage area normalization, represented a log10 Koc value of 3.32.
- Executive summary:
The HPLC estimation method based on soil-adsorption reference data was used for the determination of the adsorption coefficient (Koc) of the substance. The study was performed in accordance with EC C.19 and OECD 121 and in compliance with GLP. The mobile phase was 55/45 (v/v) methanol/water and the wavelength of detection 210 nm. The stationary phase contained a cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties. Formamide was used as unretained substance. The column temperature was 30°C and the pH of the mobile phase was 6.2. Duplicate injections of reference substances and test substance were applied. The chromatogram of the test substance showed seven test substance peaks. The log Koc value of the substance was determined to range between 1.58 and 4.25. The main constituent detected, contributing 84% of the total area by percentage area normalization, represented a log Koc value of 3.32 (Koc= 2089.3).
Reference
The retention times of the dead time and the retention times, capacity factors (k') and log10 Kocvalues for the reference standards are shown in the following table:
Standard |
Retention Time (mins) |
Mean Retention Time (mins) |
Capacity Factor (k') |
Log10k' |
Log10Koc |
|
Injection 1 |
Injection 2 |
|||||
Formamide (dead time) |
1.914 |
1.917 |
1.915 |
- |
- |
- |
Acetanilide |
2.606 |
2.606 |
2.606 |
0.360 |
-0.443 |
1.25 |
Atrazine |
3.581 |
3.581 |
3.581 |
0.870 |
-6.07 x 10-2 |
1.81 |
Isoproturon |
3.811 |
3.811 |
3.811 |
0.990 |
-4.42 x 10 -3 |
1.86 |
Triadimenol |
5.058 |
5.061 |
5.059 |
1.642 |
0.215 |
2.40 |
Linuron |
5.160 |
5.155 |
5.158 |
1.693 |
0.229 |
2.59 |
Naphthalene |
4.491 |
4.491 |
4.491 |
1.345 |
0.129 |
2.75 |
Endosulfan-diol |
6.288 |
6.291 |
6.289 |
2.284 |
0.359 |
3.02 |
Fenthion |
7.542 |
7.545 |
7.544 |
2.939 |
0.468 |
3.31 |
α-Endosulfan |
10.592 |
10.582 |
10.587 |
4.528 |
0.656 |
4.09 |
Phenanthrene |
8.224 |
8.222 |
8.223 |
3.293 |
0.518 |
4.09 |
Diclofop-methyl |
11.383 |
11.385 |
11.384 |
4.944 |
0.694 |
4.20 |
DDT |
22.086 |
22.086 |
22.086 |
10.531 |
1.02 |
5.63 |
The retention times, capacity factor and log10Kocvalue determined for the sample
Peak number |
Injection |
Retention time (mins) |
Capacity Factor (k')
|
Log10 k'
|
Log10 Koc
|
Mean Log10Koc
|
Adsorption Coefficient
|
1 |
1 |
3.287 |
0.716 |
-0.145 |
1.58 |
1.58 |
38.3 |
2 |
3.295 |
0.720 |
-0.143 |
1.59 |
|||
2 |
1 |
4.187 |
1.186 |
7.42 x 10^-2 |
2.30 |
2.30 |
198 |
2 |
4.190 |
1.188 |
7.46 x 10^-2 |
2.30 |
|||
3 |
1 |
5.075 |
1.650 |
0.217 |
2.76 |
2.76 |
571 |
2 |
5.041 |
1.632 |
0.213 |
2.75 |
|||
4 |
1 |
6.596 |
2.444 |
0.388 |
3.32 |
3.32 |
2.10 x 10^3
|
2 |
6.596 |
2.444 |
0.388 |
3.32 |
|||
5 |
1 |
8.256 |
3.310 |
0.520 |
3.75 |
3.75 |
5.64 x 10^3
|
2 |
8.241 |
3.303 |
0.519 |
3.75 |
|||
6 |
1 |
8.996 |
3.697 |
0.568 |
3.91 |
3.90
|
7.99 x 10^3
|
2 |
8.925 |
3.660 |
0.563 |
3.90 |
|||
7 |
1 |
10.895 |
4.688 |
0.671 |
4.25 |
4.25
|
1.77 x 10^4
|
2 |
10.895 |
4.688 |
0.671 |
4.25 |
Description of key information
The HPLC estimation method based on soil-adsorption reference data was used for the determination of the adsorption coefficient (Koc) of the substance. The study was performed in accordance with EC C.19 and OECD 121 and in compliance with GLP. The mobile phase was 55/45 (v/v) methanol/water and the wavelength of detection 210 nm. The stationary phase contained a cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties. Formamide was used as unretained substance. The column temperature was 30°C and the pH of the mobile phase was 6.2. Duplicate injections of reference substances and test substance. The chromatogram of the test substance showed seven test substance peaks. The log Koc value of the substance was determined to range from 1.58 to 4.25. The main constituent detected, contributing 84% of the total area by percentage area normalization, represented a log Koc value of 3.32 (Koc = 2089.3).
Key value for chemical safety assessment
- Koc at 20 °C:
- 2 089.3
Additional information
Key value is from the most representative constituent (peak #4), 84% of total area.
[LogKoc: 3.32]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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