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EC number: 288-509-6 | CAS number: 85736-97-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-Propenoic acid, 2-methyl-, C11-14-isoalkyl esters, C13-rich
- EC Number:
- 288-509-6
- EC Name:
- 2-Propenoic acid, 2-methyl-, C11-14-isoalkyl esters, C13-rich
- Cas Number:
- 85736-97-6
- Molecular formula:
- Unspecified
- IUPAC Name:
- 11-methyldodecyl 2-methylprop-2-enoate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- BOR:WISW (SPF TNO)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: F. Winkelmann GmbH & Co KG (D-4799 Borchen)
- Age at study initiation: 9 weeks
- Weight at study initiation: males 215.3 g (mean), females 162.1 g (mean)
- Fasting period before study: yes, overnight
- Housing: groups of 5
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 12 d
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 5 mL7kg bw
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical examination twice a day, bodyweights at start and termination of teh test
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights (lung , livers, kidneys, spleens, adrenals and testes)
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- Mortality was neither observed in the experimental group nor in the controls during the observation period of 14 days.
- Clinical signs:
- The clinical appearance and behavior of the male and fema.le rats did not differ from the controls for the wIlole experimental period. The day of and after administration the faeces of the experimental rats were covered by a
oily film, but were of normal viscocity. - Body weight:
- Body weight gain in the experimental group was comparable to the control animals.
- Gross pathology:
- At necropsy no substance-related signs of toxicity were found in comparison to the controls. The only observation was a similar incidence of white foci on the lung surface of the experimental and control rats.
- Other findings:
- It was found that except of significantly higher mean testes (p < 0.01) and adrenal (p < 0.05) weights in the male rats the experimental results did not differ from those of the controls. These differences were rather small and do not demonstrate a toxic effect of the test substance.
Any other information on results incl. tables
Tissue weight (g) of male and female rats after oral treatment with the test item
|
Male rats |
|
Female rats |
|
|
Controls |
Experimental |
Controls |
Experimental |
Lung |
1.12 ± 0.09 |
1.07 ± 0.09 |
0.87 ± 0.07 |
0.89 ± 0.08 |
Liver |
10.37 ± 1.65 |
10.15 ± 1.08 |
6.16 ± 0.64 |
6.55 ± 0.44 |
Kidneys |
1. 76 ± 0.28 |
1.71 ± 0.17 |
1.15 ± 0.07 |
1.18 ± 0.06 |
Adrenals |
0.043 ± 0.004 |
0.047 ± 0.006* |
0.06 ± 0.01 |
0.06 ± 0.01 |
Spleen |
0.57 ± 0.12 |
0.60 ± 0.12 |
0.38 ± 0.04 |
0.42 ± 0.07 |
Testes |
3.19 ± 0.05 |
2.94 + 0.14** |
|
|
* p <0.05
** P <0.01
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral LD50 of Isotridecyl methacrylate was >5000 mg/kg bw in rat.
- Executive summary:
In an acute oral toxicity study according to OECD Guideline 401, groups of fasted, 9 weeks old Wistar rats (5/sex) were given a single oral dose of Isotridecyl methacrylate at a limit dose of 5000 mg/kg bw and observed for 14 days. Untreated control animals were included. During an observation period of 14 days there was neither lethality nor toxicity in relation to the treatment of the substance.
Oral LD50 combined >5000 mg/kg bw
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