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EC number: 239-914-1 | CAS number: 15816-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In aqueous systems Octanoic acid, compound with dicyclohexylamine (1:1) is hydrolytically very unstable so that in aqueous solution a rapid decomposition to the educts can be observed.The substance will rapidly dissociate to octanoic acid and dicyclohexylamine. The time of decomposition was estimated as < 8 minutes. Therefore Octanoic acid, compound with dicyclohexylamine (1:1) is not stable at “standard” testing conditions representative for human and environmental exposure. Hence, it is fully justified to apply the read-across methodology by use of the respective data from the breakdown/decomposition products to describe the toxicological behaviour of the substance to be registered.
Octanoic acid:
Acute toxicity oral:
An evaluation of available acute oral toxicity data is given in the CLH-Report prepared by Umweltbundesamt GmbH
on behalf of AT Competent Authority, Federal Ministry of Agriculture, Forestry, Environment and WaterManagement.
No classification for acute oral toxicity is required. Also according to the HERA (Human Health Risk Assessment) Targeted Risk Assessmentf or fatty acids salts no classification is needed. Citation from HERA: "The available data for fatty acids provide a clear picture of low acute toxicity for this class of chemicals. All oral LD50 values were greater than 2,000 mg/kg, with little mortality being observed even at the highest doses tested in the studies."
Acute Toxicity inhalation:
6 male or female Albino rabbits were exposed to saturated octanoic acid vapour for 4 hours No mortality was observed. The LC50 was >5 ml/l
Acute dermal toxicity:
The acute dermal toxicity study in rats indicate an LD50 above 2000 mg/kg bw, which is above the LD50 range that may lead to classification in category 4 (1000 to 2000 mg/kg bw).
DCHA:
Acute oral toxicity:
The acute oral toxicity of dicyclohexylamine was evaluated in male Wistar rats. The test substnace was administered oral by gavage at doses of 0.16, 0.18, 0.20, 0.25, 0.30 ml/mg/ bw to groups of 10 male animals. Signs of intoxication were tonical cramps, sedation, poor general condition. The LD50 was estimated as 200 mg/kg bw.
Acute toxicity inhalation:
In an acute inhalation toxicity study in 6 male New Zealand Albino rabbits the LC 50 of Dicyclohexylamine was determined as > 1.4 mg/l.
Acute dermal toxicity:
Groups of New Zealand White rabbits received 126 - 316 mg/kg bw undiluted dicyclohexylamine by dermal application for 24 hours and were then observed for 14 days. Signs of intoxication were reduced appetite and activity, increasing weakness, collapse, and death within 16 hours post application from 200 mg/kg bw upwards. The LD50 ranges between 200 and 316 mg/kg bw.
The lowest respective LD50/LC50 is calculated for the entire substance considering the molar mass of 325.5 g/mol forOctanoic acid, compound with N-cyclohexylcyclohexanamine (1:1), 181.32 for DCHA and 144.21 for octanoic acid respectively.
Therefore the respective LD50's/LC50 for Octanoic acid, compound with dicyclohexylamine (1:1) are:
Acute oral toxicity:
LD50: 359 mg/kg b.w.
Acute dermal toxicity:
LD50: 359 mg/kg b.w.
Acute toxicity inhalation:
As for both substances neither mortality, nor significant clinical signs or pathological findings are reported at the highest doses apllied the LC50 for Octanoic acid, compound with dicyclohexylamine (1:1) is set as > 5 mg/l.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single oral application by gavage, undiluted test substance., 5 doses, observation time 14 days, determination of signs of intoxication, stat.method:probit analysis.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 0.16, 0.18, 0.20, 0.25, 0.30 ml/mg/ bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Dose: number of dead animals (time of death)// number of rats with symptoms 0.16 ml/kg bw: 0/10 (-) // 10/10 0.18 ml/kg bw: 1/10 (3h) // 10/10 0.20 ml/kg bw: 5/10 (3h) // 10/10 0.25 ml/kg bw: 7/10 (3h) // 10/100.30 ml/kg bw: 10/10 (2h-2d) // 10/10
- Clinical signs:
- tonical cramps, sedation, poor general condition
- Body weight:
- no data
- Gross pathology:
- no data
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The acute oral toxicity of dicyclohexylamine was evaluated in male Wistar rats. The test substnace was administered oral by gavage at doses of 0.16, 0.18, 0.20, 0.25, 0.30 ml/mg/ bw to groups of 10 male animals. Signs of intoxication were tonical cramps, sedation, poor general condition. The LD50 was estimated as 200 mg/kg bw.
- Executive summary:
The acute oral toxicity of dicyclohexylamine was evaluated in male Wistar rats. The test substnace was administered oral by gavage at doses of 0.16, 0.18, 0.20, 0.25, 0.30 ml/mg/ bw to groups of 10 male animals. Signs of intoxication were tonical cramps, sedation, poor general condition. The LD50 was estimated as 200 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 359 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- other: literature data
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- fixed concentration procedure
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 6 h
- Concentrations:
- 1.4 mg/l
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- Chamber volume: 35 l
Air flow rate: 4.0 l/min
Vaporized sample: 2.1 g - Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 1.4 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Mortality:
- none
- Clinical signs:
- other: slight lethargy
- Body weight:
- not specified
- Gross pathology:
- no effects observed
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute inhalation toxicity study in 6 male New Zealand Albino rabbits the LC 50 of Dicyclohexylamine was determined as > 1.4 mg/l.
- Executive summary:
In an acute inhalation toxicity study in 6 male New Zealand Albino rabbits the LC 50 of Dicyclohexylamine was determined as > 1.4 mg/l.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 5 000 mg/m³
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- other: literature data
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Type of coverage:
- not specified
- Vehicle:
- polyethylene glycol
- Duration of exposure:
- 24 hours
- Doses:
- not specified
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- Reversible
skin irritation in all animals, moderate sedation, deep respiration, hunched posture - Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute dermal toxicity study in rats indicate an LD50 above 2000 mg/kg bw, which is above the LD50 range that may lead to classification in category 4 (1000 to 2000 mg/kg bw).
- Executive summary:
The acute dermal toxicity study in rats indicate an LD50 above 2000 mg/kg bw, which is above the LD50 range that may lead to classification in category 4 (1000 to 2000 mg/kg bw).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 359 mg/kg bw
Additional information
Justification for classification or non-classification
Acute oral toxicity:
According to the CLP Regulation (EU GHS Regulation (EC) No 1272/2008) classification and labelling is required for
Octanoic acid, compound with dicyclohexylamine (1:1) for acute oral toxicity, based on acute oral toxicity value of 359 mg/kg bw. Therefore the substance is classified in category 4 (H312, harmful if swallowed).
Acute dermal toxicity:
According to the CLP Regulation (EU GHS Regulation (EC) No 1272/2008) classification and labelling is required for
Octanoic acid, compound with dicyclohexylamine (1:1) for acute dermal toxicity, based on acute dermal toxicity value of 359 mg/kg bw. Therefore the substance is classified in category 3 (H312, toxic in contact with skin).
Acute toxicity inhalation:
The respective criteria are not met.
The estimated LC50 is > 5 mg/l.
Octanoic acid, compound with dicyclohexylamine (1:1)
is therefore not classified for acute toxicity by inhalation.
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