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EC number: 233-340-5 | CAS number: 10124-53-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity values (oral, dermal and inhalative) were determined for
magnesium thiosulfate utilizing read-across data to sodium sulfite (CAS
7757-83-7), calcium thiosulfate (CAS 10124-41
-1) and potassium thiosulfate (CAS 10294-66-3).
Please see `discussion` below.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Read-across concept for sulfites, hydrogensulfites, metabisulfites, dithionites and thiosulfates:
A comprehensive read-across concept has been developed for sulfites, hydrogensulfites and metabisulfites, based on the pH-dependant equilibrium in aqueous solutions which is summarised in the following equations:[1],[2]
SO2+ H2O <->`H2SO3´ H2SO3<->H++ HSO3-<->2H++SO32- 2HSO3-<->H2O +S2O52-
Since the nature of the cation (i.e., sodium, potassium, ammonium…) is not assumed to contribute substantially to differences in toxicity and solubility (all compounds are very soluble in water), only the chemical and biological properties of the anion are considered as relevant determinants. Based on the described equilibrium correlations, unrestricted read-across between the groups of sulfites, hydrogensulfites and metabisulfites is considered justified.
Additionally, it is known that sodium dithionite disproportionates in water to form sodium hydrogen sulfite and sodium thiosulfate (equation II)2,[1], so that this substance can also be considered to be covered by the read-across concept described above. Since it can easily be anticipated that the substance is not stable enough under physiological conditions to fulfil the requirements of study guidelines, instead the products of decomposition have to be considered:
2 S2O42-+ H2O→2HSO3-+ S2O32-
Not fully covered by this read-across concept is the substance class of thiosulfates: although the thiosulfates are also well known to disproportionate in aqueous solution to form polythionic acids and SO2(HSO3-), this requires somewhat different, more acidic conditions. Therefore, read-across to sulfites is primarily restricted to appropriate physiological conditions, i.e. oral administration where the gastric passage with the strongly acidic conditions in the stomach will facilitate the chemical disproportionation described above:
HS2O3-+ H2S2O3→HS3O3- + SO2+ H2O
[1]Hollemann Wiberg, Lehrbuch der Anorganischen Chemie, 101.Auflage
[2]Handbook of Chemistry and Physics, Ed. Lide, DR, 88thedition, CRC Press
Acute toxicity oral:
Three animal studies on acute oral exposure are available, conducted equivalent or similar to OECD guideline 401 or according to OECD 425.One study (Douds, 1996) indicates a LD50 value of >2500 mg/kg/bw (male and female rats) for the test item potassium thiosulfate (CAS 10294 -66 -3). One OECD 425 study (Durando, 2009) performed with calcium thiosulfate (CAS 10124 -41 -1) as test item indicated a LD50 >2000 mg/kg/bw (femal rats) and a supporting study (Lemen, 1988, reliability 3) performed with ammonium thiosulfate (CAS 7783 -18 -8) resulted in a LD50 value of about 3800 mg/kg/bw.
Acute dermal toxicity:
One study on acute dermal toxicity, performed according to OECD 402 for the test item potassium thiosulfate (7783 -18 -8) is available. LD50 value was determined to be greater than 2000 mg/kg/bw (limit test).The most notable clinical abnormalities observed during the study included transient incidences of fecal stain. Dermal irritation was noted at the sites of test article application.One supporting study (reliability 3) according to OECD 402 for the test item ammonium thiosulafte is available with a determined LD50 value of >2000 mg/kg bw.Clinical observations of all animals were normal for the 14-day observation period. Skin reactions were only observable on Day 1 and Day 3. On Day 1, erythema was observed in all the females and three of the males with one male exhibiting well-defined erythema. Very slight oedema was observed in one male only on Day 1. On Day 3, very slight erythema was observed in four animals. There were no other dermal effects observed in any of the animals.
Acute inhalation toxicity:
One study (Douds, 1996) equivalent or similar to OECD 403 for potassium thiosulfate (10294 -66 -3) has been performed which indicated a LC50 >2.6 mg/l (limit test). The most notable clinical abnormalities observed durng the study included rales, salivation, urine stain, rough haircoat and dark material around the facial area, as well as scab(s) and hairloss were observed.
One study (Klimisch, 1982) equivalent or similar to OECD 403 for sodium sulfite (CAS 7757 -83 -7) has been performed which indicated a LC50 >5.5 mg/l (limit test). During exposure nothing abnormal was detected. After exposure: substance-contaminated heads, and unstable, staggering gait. After one day nothing abnormal was detected.
Justification for classification or non-classification
Acute oral toxicity:
(for further information, please see `discussion`)
The references Douds (1996) which indicates a LD50 value of ca. 2500 mg/kg bw, and Durando (2009) with a determined LD50 of >2000 mg/kg bw are considered as key studies for acute oral toxicity and will be used for classification. Recalculation of the LD50 via SO2 equivalents to magnesium thiosulfate affords a LD50 of 2032 mg/kg bw.
According to the EC Regulation No. 1272/2008 and subsequent regulations, the test item is not classified as acute toxic via the oral route.
Based on substance specific data and supporting information from the read-across concept, classification for magnesium thiosulfate as acute toxic via oral route is not anticipated.
Specific target organ toxicant (STOT) – single exposure: oral:
The classification criteria acc. to regulation (EC) 1272/2008 as specific target organ toxicant (STOT) – single exposure, oral are not met since no reversible or irreversible adverse health effects were observed immediately or delayed after exposure and no effects were observed at the guidance value, oral for a Category 1 classification of 300 mg/kg bw and at the guidance value, oral for a Category 2 classification of 2000 mg/kg bw. No classification required.
Acute dermal toxicity:
(for further information, please see `discussion`)
The reference Douds (1996) which indicates a LD50 > 2000 mg/kg bw, is considered as the key study for acute dermal toxicity and will be used for classification.
The most notable clinical abnormalities observed during the study included transient incidences of fecal stain. Dermal irritation was noted at the sites of test article application
According to the criteria specified by Directive 67/548/EEC and subsequent regulations, the test item is not classified as acute toxic via the dermal route. According to the EC Regulation No. 1272/2008 and subsequent regulations, the test item is not classified as acute toxic via the dermal route.
Based on the read-across concept, classification for magnesium thiosulfate as acute toxic via dermal route is not anticipated.
Acute inhalation toxicity:
(for further information, please see `discussion`)
The reference Klimisch (1982) which indicates a LC50 value of > 5.5 mg/l, is considered as the key study for acute inhalation toxicity and will be used for classification.
According to the criteria specified by Directive 67/548/EEC and subsequent regulations, the test item is not classified as acute toxic via the inhalation route. According to the EC Regulation No. 1272/2008 and subsequent regulations, the test item is not classified as acute toxic via the inhalation route.
Based on the read-across concept, classification for magnesium thiosulfate as acute toxic via inhalation route is not anticipated.
Specific target organ toxicant (STOT) – single exposure: inhalation:
The classification criteria acc. to regulation (EC) 1272/2008 as specific target organ toxicant (STOT) – single exposure, inhalation dust/mist/fume are not met since no reversible or irreversible adverse health effects were observed immediately or delayed after exposure and no effects were observed at the guidance value, inhalation dust/mist/fume for a Category 1 classification of 1.0 mg/L/4h and at the guidance value, inhalation dust/mist/fume for a Category 2 classification of 5.0 mg/L/4h. Therefore, no classification is required. Finally, any category 3 classification should primarily be based on human data. However, such classification is also not warranted, since only unspecific observations in test animals (mainly rats) were observed at artificially high inhalation exposure levels which are without relevance to current workplace conditions. It can be safely assumed that standard occupational hygiene measures provide a sufficient level of worker protection.
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