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Diss Factsheets
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EC number: 947-660-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September, 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- (1981)
- Deviations:
- yes
- Remarks:
- lack of the study design and test material details in the report
- GLP compliance:
- no
- Remarks:
- (study performed prior to GLP was in place)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Acid Catalysed Reaction Products of 3,7-dimethyl-2,6-octadienal in the presence of ethanol
- IUPAC Name:
- Acid Catalysed Reaction Products of 3,7-dimethyl-2,6-octadienal in the presence of ethanol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
No data
ENVIRONMENTAL CONDITIONS
No data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data
- Duration of exposure:
- No data
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 10 animals (sex unknown)
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Frequency of weighing: no data
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1 animal died on day 14
- Clinical signs:
- Diarrhea, difficulty in walking due to severe skin reaction, lethargy, emaciation, ataxia, yellow nasal discharge, adipsia, anorexia, tachypnea, mucous in stool, respiratory rattle (no data about which clinical sign when was observed in which animal).
- Body weight:
- No data
- Gross pathology:
- See section "Any other information on results incl. tables"
- Other findings:
- - Erythema (redness) (day 1): Moderate in 4 of the 10 animals; Severe in 6 of the 10 animals
- Edema (day 1): Moderate in 10 of the 10 animals
Any other information on results incl. tables
Necropsy observations; Number of animals |
|
Normal |
3 |
Exudate, nose/mouth yellow |
1 |
Exudate, anogenital, brown |
1 |
Intestines, areas yellow |
1 |
Intestines, bloated |
3 |
Liver dark |
1 |
Liver, mottled |
1 |
Lungs, areas dark |
2 |
Lungs, bright orange |
2 |
Kidney dark |
2 |
Kidney, mottled |
2 |
Kidney, white nodules |
1 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute dermal toxicity study with 10 rabbits, performed equivalent to OECD 402 (1981), a LD50 of >5000 mg/kg bw was determined.
- Executive summary:
The substance was tested in an acute dermal toxicity study (limit test) with 10 rabbits, performed equivalent to OECD 402 (1981). One animal died on day 14. Diarrhea, difficulty in walking due to severe skin reaction, lethargy, emaciation, ataxia, yellow nasal discharge, adipsia, anorexia, tachypnea, mucous in stool and respiratory rattle was observed among the animals. Moderate to severe erythema and moderate edema was observed on day 1. Based on the results, a LD50 of >5000 mg/kg bodyweight was determined. Based on this result, the substance does not need to be classified for acute toxicity by the dermal route in accordance with the CLP Regulation.
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