Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 921-136-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2005-09-13 to 2005-12-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- According to guideline
PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): SPAN 60
- Concentration of vehicle in test medium (stock solution and final test solution(s) at different concentrations and in control(s)):
- Nominal values
Substance Concentration Solubilizer SPAN-60
pos. Control 0.05 mg/L -
pos. Control 0.5 mg/L -
Test item: 107.5 mg/L 800 mg/L
Vehicle
Control: - 800 mg/L
Negative
Control - - - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Weight: 0.22 +/- 0.02 g
Length: 3.1 +/- 0.2 cm
Lot: 50729
Date: 2005-07-29 - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- no
- Test temperature:
- 24.5 +/- 0.8 °C
- Nominal and measured concentrations:
- 107.5 mg/L
- Details on test conditions:
- 10 fish per 4 L
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 107.5 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: with SPAN 60 as solibiliser
- Sublethal observations / clinical signs:
- Mortality of control: 0 % after 96 hours
Mortality in %
Sample Mortality / [%] Test Material Concentration / [mg/L] 24 h 48 h 72 h 96 h Positive Control 0.5 20 70 100 100 Positive Control 0.05 0 0 0 0 Test material (+vehicle) 107.5 0
0
0 0
SPAN-60
800
0
0
0
0
Blank
0
0
0
0
0
All concentrations tested were at or above the solubility limit of the pure test substance. To achive the exposure concentrations, solubiliser was used.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50 of the test material exceeds 107.5 mg/L and is clearly above the limit of water solubility.
- Executive summary:
The acute toxicity of the test material was studied in a pretest for a bioaccumulation study (OECD TG 305) using solvents to increase exposure. The GLP test was performed according to the METI Guideline: Concentration Test on Chemical Substances in Fish. For this assay a pre-test on acute toxicity in fish according to OECD 203 was performed with Danio rerio.
To achieve the exposure concentrations of 107.5 mg/L, solvent SPAN 60 (800 mg/L) was used. All concentrations tested were at or above the solubility limit of the pure test substance.
Negative control and vehicle control did not show signs of toxicity. The positive showed mortality in the expected concentration range.
At a test material concentration of 107.5 mg/L, adjusted with solubilizer, no mortality was observed after 24, 48, 72 and 96 hours, respectively. The test material does not possess acute toxic potential to fish up to the limit of solubility in water. The 96 hours LC50 exceeds the water solubility limit of the pure substance.
The LC50 of the test material exceeds 107.5 mg/L and is clearly above the limit of water solubility.
Reference
Description of key information
The LC50 of the test material exceeds 107.5 mg/L and is clearly above the limit of water solubility.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 107.5 mg/L
Additional information
The acute toxicity of the test material was studied in a pretest for a bioaccumulation study (OECD TG 305) using solvents to increase exposure. The GLP test was performed according to the METI Guideline: Concentration Test on Chemical Substances in Fish. For this assay a pre-test on acute toxicity in fish according to OECD 203 was performed with Danio rerio.
To achieve the exposure concentrations of 107.5 mg/L, solvent SPAN 60 (800 mg/L) was used. All concentrations tested were at or above the solubility limit of the pure test substance.
Negative control and vehicle control did not show signs of toxicity. The positive showed mortality in the expected concentration range.
At a test material concentration of 107.5 mg/L, adjusted with solubilizer, no mortality was observed after 24, 48, 72 and 96 hours, respectively. The test material does not possess acute toxic potential to fish up to the limit of solubility in water. The 96 hours LC50 exceeds the water solubility limit of the pure substance.
The LC50 of the test material exceeds 107.5 mg/L and is clearly above the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.