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EC number: 259-467-6 | CAS number: 55067-10-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- From 11th to 22nd November 1991.
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- A new version of the guidance was published after release of the study report.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Test material: CYDI ((1,4,5,6-Tetrahydro-4,6-dioxopyrimidin-2-yl)cyanamide)
Description: Off-white powder
Storage: In original container at room temperature
Molecular formula: C5H4N4O2 - Analytical monitoring:
- no
- Vehicle:
- yes
- Remarks:
- Preliminary solution in 1% Tween 80-dimethylsulphoxide
- Details on test solutions:
- 10 mg/L was the highest test concentration that could be prepared due to the limited solubility of the test material in water and auxiliary solvent and having due regard to the amount of auxiliary solvent permitted in the test under the OECD Guidelines. Other combinations of the various recognised auxiliary solvents and mixtures of Tween 80 (up to 20% Tween 80 in solvent) were used during the range-finding experiment, however the comb'ination of 1% Tween 80-dimethylsulphoxide was found to give the best testable dispersion of the test material in water. At higher test concentrations there was a marked precipitation of the test material on addition of the solvent stock solution to water.
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- Test species: Rainbow trout (Oncorhynchus mykiss).
Length: 4.6 ± 0.2 cm.
Weight: 1.28 ± 0.28 g (Loading: 0.64g bodyweight/litre).
Supplier: Parkwood Trout Farm, Kent, U.K.
Mortalities: Zero in the seven days prior to the start of the test.
Medication: None. - Test type:
- not specified
- Water media type:
- freshwater
- Remarks:
- Dechlorinated tap water
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- Approximately 50 mg/l as CaCO3
- Test temperature:
- 14°C
- pH:
- Not specified.
- Dissolved oxygen:
- Not specified.
- Salinity:
- Not specified.
- Conductivity:
- Not specified.
- Nominal and measured concentrations:
- Nominal concentrations: 0.1, 1 and 10 mg/L.
- Details on test conditions:
- Tes vessels: 20L.
Aeration: Yes. - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 mg/L
- Details on results:
- No mortality was observed at any of the tested concentrations (0.1, 1 and 10 mg/L) during the preliminary range-finding study.
2 replicates of the highest tested concentration (10 mg/L) were then performed. No mortality was observed. - Sublethal observations / clinical signs:
Table 1: Results of the preliminary range-finding test
Concentration
(mg/L)
Cumulative Mortality (initial population = 2)
24 Hours
48 Hours
72 Hours
96 Hours
Control
0
0
0
0
Solvent Control
0
0
0
0
0.10
0
0
0
0
1.0
0
0
0
0
10
0
0
0
0
Table 2: Results of the mortality study on the highest test substance concentration
Concentration (mg/1 )
Cumulative
Mortality (initial population = 10)
24 hours
48 Hours
72 Hours
96 Hours
Control
0
0
0
0
Solvent Control
0
0
0
0
10 R1
0
0
0
0
10 R2
0
0
0
0
R1 = first repetition; R2= second repetition
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The LC50 of (1,4,5,6-Tetrahydro-4,6-dioxopyrimidin-2-yl)cyanamide could not be determined as no mortality was observed at any tested concentration during the study.
The LC50 of (1,4,5,6-Tetrahydro-4,6-dioxopyrimidin-2-yl)cyanamide was therefored determined to be > 10mg/L for 96h exposure. - Executive summary:
The acute toxicity to fish (Oncorhynchus mykiss) of CYDI ((1,4,5,6-Tetrahydro-4,6-dioxopyrimidin-2-yl)cyanamide) was evaluated.
The results indicate that none of the tested concentrations (0.1, 1 and 10 mg/L) in test substance cause mortality to fish after 96 hours exposure.
The LC50,96h of (1,4,5,6-Tetrahydro-4,6-dioxopyrimidin-2-yl)cyanamide to fish was therefore determined to be > 10mg/L.
This result indicates that (1,4,5,6-Tetrahydro-4,6-dioxopyrimidin-2-yl)cyanamide should not be classified for Aquatic Acute Toxicity according to CLP ( Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures).
Reference
Description of key information
The acute toxicity to fish (Oncorhynchus mykiss) of CYDI ((1,4,5,6-Tetrahydro-4,6-dioxopyrimidin-2-yl)cyanamide) was evaluated.
The results indicate that none of the tested concentrations (0.1, 1 and 10 mg/L) in test substance cause mortality to fish after 96 hours exposure.
The LC50,96hof (1,4,5,6-Tetrahydro-4,6-dioxopyrimidin-2-yl)cyanamide to fish was therefore determined to be > 10mg/L.
This result indicates that (1,4,5,6-Tetrahydro-4,6-dioxopyrimidin-2-yl)cyanamide should not be classified for Aquatic Acute Toxicity according to CLP ( Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures).
The value of 10mg/L is mentionned to be the solubility limit of the test item and no death was observed so no LC50 value higher than 10 mg/L can be derived, meaning that (1,4,5,6-Tetrahydro-4,6-dioxopyrimidin-2-yl)cyanamide should not be classified for Aquatic Chronic Toxicity according to CLP.
Key value for chemical safety assessment
Additional information
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