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EC number: 240-211-7 | CAS number: 16066-38-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dipropyl peroxydicarbonate
- EC Number:
- 240-211-7
- EC Name:
- Dipropyl peroxydicarbonate
- Cas Number:
- 16066-38-9
- Molecular formula:
- C8H14O6
- IUPAC Name:
- 1-({[(propoxycarbonyl)peroxy]carbonyl}oxy)propane
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Myrtle's Rabbitry, Thompson Station, TN
- Age at study initiation: no data
- Weight at study initiation: no data
- Housing: individually in suspended stainless steel cages
- Diet: PMI Certified Rabbit Chow #5322 (Purina Mi lis, lnc.) was provided ad libitum
- Water: Municipal tap water treated by reverse osmosis was available ad libitum
- Acclimation period: a minimum of five days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 66-71
- Humidity (%): 67-84
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 1, 24, 48 and 72 hours and up to 21 days after dosing
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): physiological saline
- Time after start of exposure: 24 h
SCORING SYSTEM: Draize scores
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 21 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 2
- Reversibility:
- fully reversible within: 10 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 days
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Exposure to the test article produced corneal opacity in 6/6 test eyes by the 24 hour scoring interval and was confirmed by positive fluorescein dye retention. The corneal opacity resolved in 4/6 test eyes by the 72 hour scoring interval and in the remaining two test eyes by study days 10 and 21, respectively. Iritis was observed in 6/6 test eyes at the 24 hour scoring interval and resolved completely in 4/6 test eyes by the 72 hour scoring interval and in the remaining two by study day 1O. Conjunctivitis (redness, swelling and discharge) was noted in 6/6 test eyes at the 1 hour scoring interval. The conjunctival irritation resolved completely in 3/6 animals by study day 14 but persisted in the remaining 3 animals (with scores of 1 for redness and/or swelling through the study day 21 scoring interval). Additional ocular findings included sloughing of the corneal epithelium which was noted in 2/6 test eyes and blanching of conjunctival tissue which was noted in 1/6 test eyes.
No corneal opacity, iritis or conjunctivitis was observed in the control eyes.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Lupersol 221 is considered to be a severe irritant to the ocular tissue of the rabbit
- Executive summary:
The potential irritant and/or corrosive effects of Lupersol 221 were evaluated on the eyes of New Zealand White rabbits. Each of six rabbits received a 0.1 ml dose of the test article in the conjunctival sac of the right eye. The contralateral eye of each animal remained untreated and served as a control. Test and control eyes were examined for signs of irritation for up to 21 days following dosing. Exposure to the test article produced corneal opacity in 6/6 test eyes by the 24 hour scoring interval and was confirmed by positive fluorescein dye retention. The corneal opacity resolved in 4/6 test eyes by the 72 hour scoring interval and in the remaining two test eyes by the study days 10 and 21, respectively. Iritis was observed in 6/6 test eyes at the 24 hour scoring interval and resolved completely in all animals by study day 10. Conjunctivitis (redness, swelling and discharge) was noted in 6/6 test eyes at the 1 hour scoring interval. The conjunctival irritation resolved completely in 3/6 animals by study day 14 but persisted in the remaining 3 animals through the study day 21 scoring interval (with scores of 1 for redness and/or swelling through the study day 21 scoring interval). Additional ocular findings included sloughing of the comeal epithelium which was noted in 2/6 test eyes and blanching of conjunctival tissue which was noted in 1/6 test eyes. Mean scores over 24, 48 and 72 hours were 1.2, 0.7, 2.0 and 2.0 for corneal opacity, iritis, conjunctival effects and chemosis, respectively. Under the conditions of this test, Lupersol 221 is considered to be a severe irritant to the ocular tissue of the rabbit.
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