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Diss Factsheets
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EC number: 203-517-1 | CAS number: 107-74-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Development and Validation of an Alternative Dermal Sensitization Test: The Mouse Ear Swelling Test (MEST)
- Author:
- Gad SC, Dunn BJ, Dobbs DW, Reilly C, Walsh RD
- Year:
- 1 986
- Bibliographic source:
- Toxicology and Applied Pharmacology 84: 93-114
Materials and methods
- Principles of method if other than guideline:
- Mouse ear swelling test
- GLP compliance:
- not specified
- Type of study:
- mouse ear swelling test
- Justification for non-LLNA method:
- Existing study.
Test material
- Reference substance name:
- 3,7-dimethyloctane-1,7-diol
- EC Number:
- 203-517-1
- EC Name:
- 3,7-dimethyloctane-1,7-diol
- Cas Number:
- 107-74-4
- Molecular formula:
- C10H22O2
- IUPAC Name:
- 3,7-dimethyloctane-1,7-diol
- Test material form:
- liquid
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CF-1
- Sex:
- female
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, open
- Vehicle:
- other: Ethanol 95%
- Concentration / amount:
- 50%
Challenge
- No.:
- #1
- Route:
- epicutaneous, open
- Vehicle:
- other: Ethanol 95%
- Concentration / amount:
- 50%
- No. of animals per dose:
- 10-15 (control 5-10)
- Details on study design:
- On the first day of the study the animals abdomens were clipped and tape stripped and two intradermal injections totaling 0.05 ml of Freund's Complete Adjuvant were administered.
A 50% solution in 95% ETOH, 100 μl, was applied to the shaved area on the first day and the following 3 days, with the skin being tape stripped before each application.
After a 7 day nontreatment period, a topical application of 20 μl of a 50% solution in 95% ETOH, was made to the left ear of the mouse while the right ear received 20 μl of the vehicle alone.
The ear thickness was measured 24 and 48 h after the challenge application.
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 50%
- No. with + reactions:
- 2
- Total no. in group:
- 10
- Clinical observations:
- The percentage swelling was reported as 114%, with a value of 100% indicating no swelling.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to the results of MEST in mice the substance is not to be classified with only 20% of sensitised animals and the swelling is below the threshold of 20% (here: 14%)
- Executive summary:
According to the results of MEST in mice the substance is not to be classified with only 20% of sensitised animals and the swelling is below the threshold of 20% (here: 14%)
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