Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-465-5 | CAS number: 2157-01-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- no GLP
- Justification for type of information:
- Read across from the 2 Ethylhexyl methacrylate category member donor substance.
REPORTING FORMAT FOR THE CATEGORY APPROACH
see attached category document
PM_Lower Alkyl (C1-C8) Methacrylates
This is a category (C1-C8 Lower Alkyl Methacrylates) with clear trends in the physicochemical properties of its members, related to molecular weight, molecular size and hydrophilicity.
The substances of the category C1-C8 Lower Alkyl Methacrylates are all readily biodegradable. This was demonstrated in several guideline studies which cover the range of C1 to C8. Please see Chapter 4.1.2.1.1 Results on screening tests for biodegradation in water). - Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Details on test conditions:
- -Preliminary Test
a) Water Temperature: 50 ºC
b) Nominal Concentration: ca. 0.5 mg/L
c) pH: pH 4 and 7
d) Number of Replicates: 2
e) Test Period: 5 days
f) Exposure Vessel Type: Glass Vial
-Final Test
a) Water Temperature: pH9; 60, 70, 80 ºC
b) Nominal Concentration: ca. 0.5 mg/L
c) pH: pH 9
d) Number of Replicates: 2 - Number of replicates:
- preliminary test =2 replicates
- Transformation products:
- not specified
- pH:
- 4
- Temp.:
- 50 °C
- Remarks on result:
- other: stable
- pH:
- 7
- Temp.:
- 50 °C
- Remarks on result:
- other: stable
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- 58.7 d
- Conclusions:
- Using a valid modeling method, the test substance was stable at pH 4 and pH 7, both at 50 ºC. The half life and the rate constant of this chemical at pH 9 were 58.7 days and 4.92 E-4/hour, at 25 ºC in water, respectively.
- Executive summary:
Using a valid modeling method, the test substance was stable at pH 4 and pH 7, both at 50 ºC. The half life and the rate constant of this chemical at pH 9 were 58.7 days and 4.92 E-4/hour, at 25 ºC in water, respectively.
Reference
-Test substance was stable at pH 4 and pH 7, both at 50 ºC in preliminary test.
-The half life and the rate constant of this chemical at pH 9 were 58.7 days and 4.92 E-4/hour, at 25 ºC in water,respectively.
Description of key information
Read across to category member 2-ethylhexyl methacrylate:
stable at pH 4 and pH 7, hydrolyses slowly at pH 9
Key value for chemical safety assessment
Additional information
Read across to category member 2-ethylhexyl methacrylate:
Abiotic degradation by hydrolysis of 2-ethylhexyl methacrylate was measured in an OECD guideline study. 2-EHMA was stable at pH 4 and pH7. At pH9 the measured half-life (t 1/2 ) for 2-EHMA at 25 °C is 58 days. Since 2-EHMA is readily biodegradable, hydrolysis appears not to be an important aqueous degradation process for this chemical.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.