Registration Dossier
Registration Dossier
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EC number: 227-217-5 | CAS number: 5718-26-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methyl 2-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)ethylidene]-1,3,3-trimethylindoline-5-carboxylate
- EC Number:
- 227-217-5
- EC Name:
- Methyl 2-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)ethylidene]-1,3,3-trimethylindoline-5-carboxylate
- Cas Number:
- 5718-26-3
- Molecular formula:
- C25H25N3O3
- IUPAC Name:
- methyl 1,3,3-trimethyl-2-[2-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)ethylidene]indoline-5-carboxylate
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- Macrolex orange 51032 (Code Nr.: 826-152)
Solid powder
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- 3 rabbits were used. Body weight approx. 2.9 kg, temperature 19-25 degree Celsius, 12/12 h dark/light rythm.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 14 days
- Number of animals:
- 3 female rabbits
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: animal 1, 2 and 3
- Time point:
- other: 1, 24,48,72 h, 7 and 14 days
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible within:
- Remarks on result:
- no indication of irritation
- Remarks:
- due to the color of the substance erythema scoring was not possible for the first 4 time points.
- Irritation parameter:
- edema score
- Basis:
- other: animal 1, 2 and 3
- Time point:
- other: 1, 24,48, 72 h, 7 and 14 days
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible within:
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
In an in vivo dermal irritation study according to OECD TG 404 no erythema or edema were observed at any time point (1h to 14 days) after exposure to 500 mg to the skin.
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