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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 446-990-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: estimated data for ADME according to toxicity and physico-chemical data available on the substance
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- estimated data for ADME according to toxicity and physico-chemical data available on the substance
- GLP compliance:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 446-990-1
- EC Name:
- -
- Molecular formula:
- C5H11O5 [C6H10O5]1.45 and C5H10O4 and C5H12O5
- IUPAC Name:
- 2-(hydroxymethyl)oxolane-3,4-diol; 5-{[2,3,4,5-tetrahydroxy-6-(xenoniooxy)hexyl]oxy}pentane-1,2,3,4-tetrol; pentane-1,2,3,4,5-pentol
- Test material form:
- liquid
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
Toxicokinetics basic parameters can be estimated according to physico-chemical and toxicity data available on the registered substance.
Physico-chemical parameters:
Molecular weight: 387 + 134 + 152
Physical state: compact waxy paste
Vapor pressure: 3.6 x 10E-4 Pa at 25 ° C
Solubility in water: 674 000 mg / L
Log Pow: -2.0 to 20 ° C
- Absorption:
No systemic effect has been observed following oral and topical administration in the animal, it is not possible to conclude on the potential for absorption of the substance and / or its degradation products by oral or dermal route. Furtermore, the substance is not irritating to the skin. According to ECHA guidance - Chapter R7C, if water solubility is above 10000 mg/l and the log Kow value below 0 the substance may be too hydrophilic to cross the lipid rich environment of the stratum corneum. Dermal uptake for these substances will be low.
- Distribution:
There are no data on the concentrations of the substance in the organs and tissues after exposure. The low log Pow (-2.0 to 20 ° C) suggests that the bioaccumulation potential is negligible.
- Metabolism: In the absence of effects of the substance on the organs including the liver in rats, and in the absence of influence of the addition of a metabolic activation system on the results (negative) of the Ames test, it is not possible to describe with certainty the potential biotransformation of the substance. However, carbohydrates and their derivatives are usually metabolised by the body being treated (in the intestinal lumen and / or by the liver) and / or by bacteria from the digestive tract.
- Excretion: In the absence of renal effects after oral administration of the substance it is not possible to conclude with certainty about possible renal excretion of the substance. However, renal excretion appears likely because of the high solubility of the substance in water (674 g / L at 20 ° C).
Toxicokinetics: There are no data on plasma levels of the substance in animals after oral administration. - Executive summary:
Toxicokinetics basic parameters can be estimated according to physico-chemical and toxicity data available on the registered substance.
Physico-chemical parameters: Molecular weight :387+134+152
Physical state: compact waxy paste
Vapor pressure: 3.6x10E-4 Paat 25 °C
Solubility in water: 674 000mg/ L
Log Pow:-2.0 to 20° C - Absorption:No systemic effecthasbeen observedfollowing oralandtopical administrationin the animal,itis not possibleto concludeonthe potential for absorptionof the substance and/ or itsdegradation productsbyoralor dermal route. Furtermore, the substance is not irritating to the skin. According to ECHA guidance - Chapter R7C, if water solubility is above 10000 mg/l and the log Kow value below 0 the substance may be too hydrophilic to cross the lipid rich environment of the stratum corneum. Dermal uptake for these substances will be low. - Distribution:Thereare no dataon the concentrations ofthe substancein the organs andtissues afterexposure.Thelow logPow (-2.0 to 20° C)suggests that thebioaccumulation potentialis negligible. -Metabolism:In the absence ofeffects of the substanceon the organsincludingthe liverin rats,andin the absence ofinfluence of the additionof a metabolicactivation systemon theresults(negative)of theAmes test,it is notpossible to describewithcertaintythepotentialbiotransformationof thesubstance.However,carbohydratesand their derivatives areusuallymetabolisedbythebody being treated(intheintestinal lumenand/orby the liver)and/orbybacteria from thedigestive tract.- Excretion:In the absence ofrenal effectsafter oraladministrationof the substanceit is notpossible to concludewith certaintyabout possiblerenal excretionof the substance.However, renalexcretionappears likelybecause ofthe high solubilityof the substancein water (674g/L at 20 °C). Toxicokinetics:There are nodata onplasma levelsof the substancein animalsafter oral administration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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