Registration Dossier
Registration Dossier
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EC number: 279-242-6 | CAS number: 79720-19-7
Endpoint summary
Administrative data
Description of key information
Relevant key information is given in the respective endpoint sections. For a summary of environmental fate properties, please see below.
Additional information
No simulation test data on biodegradability are available. Based on valid screening tests on ready biodegradability (OECD 301 B) as well as inherent biodegradability (OECD 302 C) no relevant ultimate biodegradation of the test item is to be expected in the environment.
The test item showed a slow hydrolysis rate (t1/2 = 44.3 d) for pH 9 at 20 °C, and a moderate hydrolysis rate (2.4 h ≤ t1/2 ≤ 30 d) for pH 9 at 30 and 50 °C. For pH 7 and below no hydrolysis was observed and therefore a half-life of > 1 year could be assumed for environmentally typical temperatures.
Adsorption-desorption properties were determined in a HPLC-screening test (OECD 121, RL1) performed compliant with GLP: retention time was considerably higher than that of the standard with the highest log Koc ( 4,4'-DDT; log Koc = 5.63). As a conclusion, log Koc of the test item must be higher than 5.63.
Further, from a water solubility of 6.3 mg/L and a vapour pressure of 4.3E-05 Pa a very low Henry´s law constant is calculated (2.78E-03 Pa*m^3/mol).
Accordingly, the substance is not expected to volatilize to any significant degree from water or moist soil. Neither relevant biodegradation, nor dissipation due to hydrolysis is expected. Rather, due to the high estimated organic carbon normalized adsorption coefficient, within STPs a high degree of adsorption to sludge will occur resulting in efficient removal from the water phase. Similarly, in water distribution to sediment will occur, while soil will be exposed to the compound in case of distribution of sewage sludge on agricultural soil.
A relevant bioaccumulation potential could be safely ruled out by a valid and reliable QSAR study comprising QMRF and QPRF for the key model, as well as two valid supporting models differing in methodology and corroborating results of the key model. The results of the key model (BCF 26 to 447 L/kg wet weight; US EPA T.E.S.T. v. 4.2.1 BCF Consensus Method) and the supporting models (BCF≤ 211 L/kg and BCF≤ 370 L/kg wet weight according to supporting model 1: BCFBAF v3.01; BCF<< 543 L/kg wet weight according to supporting model 2: Modified Connell Equation for neutral molecule) conclusively demonstrate that the submission substance is not bioaccumulative (BCF clearly below 2000 L/kg); and that the upper limit of the estimated BCF (447 L/kg) based on T.E.S.T. Consensus Method results (key model) will be sufficiently conservative to be used as the relevant figure for chemical risk assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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