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EC number: 216-630-6
CAS number: 1631-25-0
A Primary Skin Irritation Test in House Rabbits was undertaken on 6
rabbits in each of three groups (A-C). Hair in the flank of each animal
was shaved short, 0.5 g of the sample was spread on an adhesive tape for
patch test having a diameter of 1.0 inch, and this tape was affixed to 3
points of the shaved area in a closed state.
Group A - Mild erythema was seen after 24 hours and throughout the 5-day
observation period in 5 out of 6 animals. No edema was observed.
Group B - Mild erythema was seen after 24 hours in 5 out of 6 animals.
Erythema showed signs of relief from Day 2 or 3. Mild edema was also
seen in 3 animals but was resolved on Day 2.
Group C - After 24 hours, moderate erythema was seen in all animals.
Little relief of the symptom was seen for the 5-day observation period.
Mild or moderate edema also occurred. Slight relief was subsequently
observed, but edema was still seen in all animals on Day 5.
Based on the results of the study, N-cyclohexyl maleimide is a moderate
irritant. If on skin, washing the skin immediately with abundant running
water should reduce irritation to some extent.
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