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Diss Factsheets
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EC number: 919-489-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1985
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 2003
Materials and methods
- Type of study / information:
- study with volunteers
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was tested on human volunteers, some exhibiting eczema of various kinds.
- GLP compliance:
- no
Test material
- Reference substance name:
- Reaction mass of (2E)-Tridec-2-enenitrile and (2Z)-Tridec-2-enenitrile and (3E)-Tridec-3-enenitrile and (3Z)-Tridec-3-enenitrile
- EC Number:
- 919-489-5
- Molecular formula:
- C13H23N
- IUPAC Name:
- Reaction mass of (2E)-Tridec-2-enenitrile and (2Z)-Tridec-2-enenitrile and (3E)-Tridec-3-enenitrile and (3Z)-Tridec-3-enenitrile
1
Method
- Ethical approval:
- not applicable
- Details on study design:
- The preparation (1 % in vaseline) was tested on 50 persons (20 male, 30 female). 39 persons had eczema of various kinds. Therefore the test was conducted under especially 'hard' conditions.
- Exposure assessment:
- measured
- Details on exposure:
- TYPE OF EXPOSURE: patch skin test
TYPE OF EXPOSURE MEASUREMENT: Exposure pads
EXPOSURE LEVELS: 1 % suspension in vaseline
EXPOSURE PERIOD: 24 h
POSTEXPOSURE PERIOD: Examinations were carried out immediately after removal of the testing patch and 24 h later.
Results and discussion
- Results:
- The preparation was tolerated by all persons without pathological findings.
Applicant's summary and conclusion
- Conclusions:
- The test substance was not irritating to human skin at a concentration of 1 %.
- Executive summary:
A study (Symrise 1985180) is available which was conducted to assess the skin irritating properties of the test substance applied at a concentration of 1 % in vaseline. Among the 50 volunteers, 39 persons were known to have eczema. The test substance preparation was applied to skin sites on the shoulderblades and occluded for 24 h. Skin reactions were evaluated immediately after removing the patches and 24 hours thereafter. As a result, no reactions were observed. Thus, the test substance at a concentration of 1 % was shown to be irritating to skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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