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Diss Factsheets
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EC number: 936-610-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- reproductive toxicity, other
- Remarks:
- other: QSAR prediction
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The following prediction was performed using the OECD QSAR Toolbox by categorising using an appropriate category based on the current endpoint (DART scheme v.1.0). The prediction was further refined from a large database of metadata based on relevant subcategories.
- Justification for type of information:
- See Read Across Justification in Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- other: Target record
Reference
- Endpoint:
- reproductive toxicity, other
- Remarks:
- Toxicity to reproduction QSAR
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: QSAR conducted on read across material
- Justification for type of information:
- See Read Across Justification in Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Dose descriptor:
- other: Reproductive toxicity potential
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: Undefined reproductive toxicity potential
- Remarks on result:
- not measured/tested
- Remarks:
- The prediction was based on the undefined reproductive potential from the 5 nearest neighbours compared by prediction descriptors.
- Dose descriptor:
- other: Reproductive toxicity potential
- Generation:
- other: Not specified
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- developmental neurotoxicity
- other: Undefined reproductive toxicity potential
- Remarks on result:
- not measured/tested
- Remarks:
- The prediction was based on the undefined reproductive potential from the 5 nearest neighbours compared by prediction descriptors.
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- 23.01.2015 13:34 [R]: Undefined reproductive potential; Estimation for Reproductive toxicity
- Author:
- Anon.
- Year:
- 2 015
- Bibliographic source:
- OECD QSAR Toolbox v 3.3
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6, May/July 2008
- Principles of method if other than guideline:
- This QSAR model is based on profiling results obtained by DART scheme v 1.0. This QSAR is used for identifying chemicals with structural features associated with the potential to act as reproductive or developmental toxicants.
The outcome of the QSAR model is “Known precedent reproductive and developmental toxic potential”, if the chemical has a potential to cause toxicity.
The corresponding category is displayed in the report generated for the obtained prediction.
The other prediction results are “Not known precedent reproductive and developmental toxic potential” if the toxic potential of the input chemical is not known, and “Not covered by current version of the decision tree” if the identified structural features are not objects of the tree.
The prediction was performed using a read-across approach based on analogues within the DART v1.0 category. - GLP compliance:
- no
- Remarks:
- As no laboratory work took place, compliance with GLP is not required.
- Limit test:
- no
Test material
- Reference substance name:
- 2,2'-diallyl-4,4'-sulfonyldiphenol
- EC Number:
- 411-570-9
- EC Name:
- 2,2'-diallyl-4,4'-sulfonyldiphenol
- Cas Number:
- 41481-66-7
- Molecular formula:
- Hill formula: C18 H18 O4 S CAS formula: C18 H18 O4 S
- IUPAC Name:
- 2,2'-Diallyl-4,4'-sulfonyldiphenol
- Details on test material:
- Main constituent of the multi-constituent test material
Constituent 1
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- other: Reproductive toxicity potential
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- other: Undefined reproductive toxicity potential
- Remarks on result:
- not measured/tested
- Remarks:
- The prediction was based on the undefined reproductive potential from the 5 nearest neighbours compared by prediction descriptors.
Results: F1 generation
Effect levels (F1)
- Dose descriptor:
- other: Reproductive toxicity potential
- Generation:
- other: Not specified
- Based on:
- not specified
- Sex:
- not specified
- Basis for effect level:
- developmental neurotoxicity
- other: Undefined reproductive toxicity potential
- Remarks on result:
- not measured/tested
- Remarks:
- The prediction was based on the undefined reproductive potential from the 5 nearest neighbours compared by prediction descriptors.
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
The
prediction was based on dataset comprised from the following
descriptors: "Reproductive toxicity"
Estimation method: Takes highest mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(((("a"
and("b"
and(not
"c")) ) and
"d") and
"e") and("f"
and "g") )
Domain
logical expression index: "a"
Referential
boundary:The
target chemical should be classified as Not known precedent reproductive
and developmental toxic potential by DART scheme v.1.0
Domain
logical expression index: "b"
Referential
boundary:The
target chemical should be classified as Not categorized by OECD HPV
Chemical Categories
Domain
logical expression index: "c"
Referential
boundary:The
target chemical should be classified as C9 Aromatics hydrocarbon
solvents OR Primary amines OR Secondary amines by OECD HPV Chemical
Categories
Domain
logical expression index: "d"
Referential
boundary:The
target chemical should be classified as Discrete chemical AND
Dissociating chemical by Substance Type ONLY
Domain
logical expression index: "e"
Referential
boundary:The
target chemical should be classified as Extremely fast by Hydrolysis
half-life (pH 6.5-7.4) ONLY
Domain
logical expression index: "f"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -0.323
Domain
logical expression index: "g"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 2.43
Applicant's summary and conclusion
- Conclusions:
- Based on the modelled conditions, the substance is categorised as "Undefined reproductive potential".
- Executive summary:
The potential of the test material to cause reproductive toxicity was modelled using the OECD QSAR Toolbox. This QSAR model is based on profiling results obtained by DART scheme v 1.0. This QSAR is used for identifying chemicals with structural features associated with the potential to act as reproductive or developmental toxicants.
The prediction was performed using a read-across approach based on analogues within the DART v1.0 category.
Based on the modelled conditions, the substance is categorised as "Undefined reproductive potential". The target chemical falls within the applicability domain of the prediction.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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