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Diss Factsheets

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation, other
Remarks:
Classification based on calculation rules for mixtures of the CLP regulation
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Study period:
2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: accepted calculation method

Data source

Referenceopen allclose all

Reference Type:
other: Regulation
Title:
Regulation (EC) No 1272/2008 of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006
Year:
2008
Bibliographic source:
Regulation (EC) No 1272/2008 of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006
Reference Type:
other: Guidance
Title:
Guidance on the Application of the CLP Criteria - Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures - version 5.0
Author:
ECHA
Year:
2017
Bibliographic source:
ECHA-17-G-21-EN

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Classification based on calculation rules for mixtures of the CLP regulation

Test material

Constituent 1
Chemical structure
Reference substance name:
(R)-p-mentha-1,8-diene
EC Number:
227-813-5
EC Name:
(R)-p-mentha-1,8-diene
Cas Number:
5989-27-5
Molecular formula:
C10H16
IUPAC Name:
4-isopropenyl-1-methylcyclohexene
Constituent 2
Chemical structure
Reference substance name:
Linalool
EC Number:
201-134-4
EC Name:
Linalool
Cas Number:
78-70-6
Molecular formula:
C10H18O
IUPAC Name:
3,7-dimethylocta-1,6-dien-3-ol
Constituent 3
Chemical structure
Reference substance name:
Pin-2(10)-ene
EC Number:
204-872-5
EC Name:
Pin-2(10)-ene
Cas Number:
127-91-3
Molecular formula:
C10H16
IUPAC Name:
6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane
Constituent 4
Chemical structure
Reference substance name:
Linalyl acetate
EC Number:
204-116-4
EC Name:
Linalyl acetate
Cas Number:
115-95-7
Molecular formula:
C12H20O2
IUPAC Name:
1,5-dimethyl-1-vinylhex-4-en-1-yl acetate
Constituent 5
Chemical structure
Reference substance name:
3,7-dimethylocta-1,3,6-triene
EC Number:
237-641-2
EC Name:
3,7-dimethylocta-1,3,6-triene
Cas Number:
13877-91-3
Molecular formula:
C10H16
IUPAC Name:
3,7-dimethylocta-1,3,6-triene
Constituent 6
Chemical structure
Reference substance name:
p-menth-1-en-8-ol
EC Number:
202-680-6
EC Name:
p-menth-1-en-8-ol
Cas Number:
98-55-5
Molecular formula:
C10H18O
IUPAC Name:
p-menth-1-en-8-ol
Constituent 7
Chemical structure
Reference substance name:
7-methyl-3-methyleneocta-1,6-diene
EC Number:
204-622-5
EC Name:
7-methyl-3-methyleneocta-1,6-diene
Cas Number:
123-35-3
Molecular formula:
C10H16
IUPAC Name:
7-methyl-3-methyleneocta-1,6-diene
Constituent 8
Chemical structure
Reference substance name:
Geranyl acetate
EC Number:
203-341-5
EC Name:
Geranyl acetate
Cas Number:
105-87-3
Molecular formula:
C12H20O2
IUPAC Name:
3,7-dimethylocta-2,6-dien-1-yl acetate
Constituent 9
Chemical structure
Reference substance name:
Geraniol
EC Number:
203-377-1
EC Name:
Geraniol
Cas Number:
106-24-1
Molecular formula:
C10H18O
IUPAC Name:
3,7-dimethylocta-2,6-dien-1-ol
Constituent 10
Chemical structure
Reference substance name:
3,7,11-trimethyldodeca-1,6,10-trien-3-ol,mixed isomers
EC Number:
230-597-5
EC Name:
3,7,11-trimethyldodeca-1,6,10-trien-3-ol,mixed isomers
Cas Number:
7212-44-4
Molecular formula:
C15H26O
IUPAC Name:
3,7,11-trimethyldodeca-1,6,10-trien-3-ol
Constituent 11
Chemical structure
Reference substance name:
Nerol
EC Number:
203-378-7
EC Name:
Nerol
Cas Number:
106-25-2
Molecular formula:
C10H18O
IUPAC Name:
3,7-dimethylocta-2,6-dien-1-ol
Constituent 12
Chemical structure
Reference substance name:
Farnesol
EC Number:
225-004-1
EC Name:
Farnesol
Cas Number:
4602-84-0
Molecular formula:
C15H26O
IUPAC Name:
3,7,11-trimethyldodeca-2,6,10-trien-1-ol
Constituent 13
Chemical structure
Reference substance name:
Neryl acetate
EC Number:
205-459-2
EC Name:
Neryl acetate
Cas Number:
141-12-8
Molecular formula:
C12H20O2
IUPAC Name:
3,7-dimethylocta-2,6-dien-1-yl acetate
Constituent 14
Chemical structure
Reference substance name:
Pin-2(3)-ene
EC Number:
201-291-9
EC Name:
Pin-2(3)-ene
Cas Number:
80-56-8
Molecular formula:
C10H16
IUPAC Name:
2,6,6-trimethylbicyclo[3.1.1]hept-2-ene
Constituent 15
Chemical structure
Reference substance name:
Thuj-4(10)-ene
EC Number:
222-212-4
EC Name:
Thuj-4(10)-ene
Cas Number:
3387-41-5
Molecular formula:
C10H16
IUPAC Name:
1-isopropyl-4-methylenebicyclo[3.1.0]hexane
Constituent 16
Chemical structure
Reference substance name:
Indole
EC Number:
204-420-7
EC Name:
Indole
Cas Number:
120-72-9
Molecular formula:
C8H7N
IUPAC Name:
1H-indole
Constituent 17
Chemical structure
Reference substance name:
Methyl anthranilate
EC Number:
205-132-4
EC Name:
Methyl anthranilate
Cas Number:
134-20-3
Molecular formula:
C8H9NO2
IUPAC Name:
methyl 2-aminobenzoate
Test material form:
liquid

Results and discussion

In vitro / in chemico

Results
Key result
Parameter:
other: Classification calculation
Remarks on result:
other: Skin sensitiser category 1

Any other information on results incl. tables

See attached document

Applicant's summary and conclusion

Interpretation of results:
Category 1 (skin sensitising) based on GHS criteria
Conclusions:
Based on the CLP classification rules, applicable for NCS, the Neroli oil (CAS 8016-38-4; List Nr 639-655-8) is classified for skin sensitization : Skin Sens.1 H317
Executive summary:

The NCS is composed of several identified constituents and according to CLP articles 10 and 11, it can be treated as a mixture for classification purpose. The decision logic for classification of mixtures from the ECHA Guidance on the Application of the CLP Criteria (2017) was used to determine the skin sensitising potential of the registered substance.

The registered substance has not been tested itself in appropriate and robust in vitro or in vivo tests, but one of its constituents is classified as Skin Sens.1 H317 (linalool) and is above the CLP generic concentration limit of 1% that triggers the classification of the mixture.

Therefore, the registered substance is classified for as a skin sensitiser category 1, according to the Regulation (EC) No 1272/2008.