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Diss Factsheets
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EC number: 228-327-6 | CAS number: 6227-20-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 November 2016 to 24 April 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Principles of method if other than guideline:
- The method is in principle only applicable to substances with a logPow between -2 and 4. For this substance no other methods were suitable an a pre-test has indicated that it would be expected that the logPow would be < 0
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- < -5
- Temp.:
- 21.5 °C
- pH:
- >= 5.36 - <= 6.32
- Remarks on result:
- other: no substance found in the organic phase (LOQ 0.0140 mg/L used for calculations)
- Details on results:
- The stock solution was prepared in n-octanol saturated water in place of water saturated n-octanol. This was due to the insolubility of the test item in the organic phase.
the pH of the aqueous phase was: 5.36-6.32
pH of n-octanol saturated water: 7.79
pH of stock solution: 6.58
Pre-test results: Approximate solubility in n-octanol: <10.5 mg/L ; Approximate solubility in water: >2.5E03 mg/L; Approximate Pow : <4.2 E03; LogPow : <-2.4 - Conclusions:
- The logPow is <-5.0
- Executive summary:
In a shakeflask test the logPow of the substance was assessed to be <-5.0. Despite the limitations of the method used, it is expected to be the most appropriate method available. The substance was insoluble in octanol.
Reference
see attachment
Description of key information
In a shakeflask test the logPow of the substance was assessed to be <-5.0. Despite the limitations of the method used, it is expected to be the most appropriate method available. The substance was insoluble in octanol.
For risk assessment purposes the logKow i set at -1 (minimum value in EUSES)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1
Additional information
The substance is known to bind to cellulose via van der Waals forces, therefore adsorption to organic material cannot be excluded.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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