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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-03-23 to 1999-04-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: A sample of activated sludge was taken on 1999-03-03 from an oxidation ditch in the municipality of Berkel en Rodenrijs, the Netherlands.
- Preparation of inoculum for exposure: The sludge suspension and the water used to prepare the medium were each aerated with CO2-free air overnight before use.
- Concentration of sludge: 30mg/L - Duration of test (contact time):
- 28 d
- Initial conc.:
- 47 mg/L
- Based on:
- test mat.
- Initial conc.:
- 20 other: mg carbon per litre
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: A medium with a higher nitrogen content than that specified in the guideline was used, in order to prevent nutrient limitation during the course of the degradation study.
- Test temperature: 20 ± 2°C
- Aeration of dilution water: yes
TEST SYSTEM
- Culturing apparatus: Two-litre glass bottles closed with plastic screw caps. A 20 mL glass vial containing the CO2 absorbing fluid (5 mL of 0.4M NaOH solution) was suspended from the screw cap of each bottle.
- Number of culture flasks/concentration: Three
- Details of trap for CO2 and volatile organics if used: 5 mL of 0.4M NaOH solution
SAMPLING
- Sampling frequency: The carbon dioxide traps were removed and replaced on the following test days: 1, 3, 6, 10, 14, 17, 21, and 28
- Sampling method: CO2 absorbed was determined by titration of the sodium hydroxide with 0.1M HCl using a Metrohm 686 Titroprocessor
CONTROL AND BLANK SYSTEM
- Inoculum blank: Yes, reference substance sodium acetate
- Abiotic sterile control: Yes
- Toxicity control: Yes, reference substance sodium acetate
STATISTICAL METHODS:
The mineralisation data (% degradation) were fitted to various production equations using non-linear regression. - Reference substance:
- acetic acid, sodium salt
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 50
- Sampling time:
- 28 d
- Details on results:
- Reference substance:
Toxicity control indicated no inhibition - Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Biodegradation of 50% in 28 days (CO2 evolution) was determined in a reliable study according to an appropriate test protocol and in compliance with GLP.
Reference
Table 1: CO2 evolved (mg/L) and calculated % biodegradation for inoculum blank, test substance, reference substance and toxicity control
Type of suspension |
1d |
3d |
6d |
10d |
14d |
17d |
21d |
28d |
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CO2evolved (mg/l) |
(%) biodeg |
CO2evolved (mg/l) |
(%) biodeg |
CO2evolved (mg/l) |
(%) biodeg |
CO2evolved (mg/l) |
(%) biodeg |
CO2evolved (mg/l) |
(%) biodeg |
CO2evolved (mg/l) |
(%) biodeg |
CO2evolved (mg/l) |
(%) biodeg |
CO2evolved (mg/l) |
(%) biodeg |
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Inoculum Blank (mean of three replicates) |
1.7 |
- |
4.5 |
- |
9.0 |
- |
13.4 |
- |
16.2 |
- |
17.7 |
- |
19.2 |
- |
20.9 |
- |
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Test substance (mean of three replicates) |
4.3 |
6 |
12.1 |
17 |
23.4 |
32 |
29.2 |
40 |
32.6 |
45 |
33.5 |
46 |
34.7 |
47 |
35.9 (36.7 including CO2in the medium released by acidification) |
49 (50) |
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Reference substance (mean of two replicates) |
4.4 |
6 |
20.1 |
28 |
36.5 |
50 |
45.9 |
63 |
51.8 (56.9 including CO2in the medium released by acidification) |
71 (78) |
54.2 |
74 |
56.3 |
77 |
58.9 (62.6 including CO2in the medium released by acidification) |
81 (86) |
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Toxicity control (mean of two replicates) |
6.8 |
5 |
30.4 |
21 |
55.9 |
38 |
71.3 |
49 |
81.3 |
56 |
84.8 |
58 |
88.3 |
60 |
92.7 (96.6 including CO2in the medium released by acidification) |
63 (66) |
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Description of key information
Biodegradation in water: screening tests: 50% in 28 days (OECD Method 301B (CO2 evolution, modified Sturm test)). The silanol hydrolysis products, [3-(2,3-epoxypropoxy)propyl]silanetriol and vinylsilanetriol, are not expected to biodegrade to any significant extent.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
A reliable biodegradation study is available with the registration substance and is selected as the key study. The study was conducted according to OECD Test Guideline 301B, and gives a biodegradation result of 50% degradation in 28 days.
The constituents of the registration substance hydrolyse rapidly (half-life <12 hours at pH 7 and 25°C) to [3-(2,3-epoxypropoxy)propyl]silanetriol, vinylsilanetriol, acetic acid/acetates and methanol. The biodegradation observed in the studies is attributable to the biodegradation of acetic acid and methanol, which are readily biodegradable. Neither [3-(2,3-epoxypropoxy)propyl]silanetriol nor vinylsilanetriol are expected to biodegrade to any significant extent.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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