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Diss Factsheets
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EC number: 289-860-8 | CAS number: 90028-67-4 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Evernia furfuracea, Usneaceae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity, oral in rats: LD50 = 5020 mg/kg bw (read-across from treemoss concrete, equivalent or similar to OECD 401, non-GLP, K, Rel. 2)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, but considered sufficiently reliable for the purpose of hazard assessment.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Mice were given a single oral dose of test substance up to 5 mL/kg bw and then observed for 14 days.
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- - Name of test material: TRNO-25
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 4, 4.5 and 5 mL/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Animals were observed for mortality and clinical signs at least daily for 14 days - Preliminary study:
- Not applicable
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4.33 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 4.01 - <= 4.68
- Mortality:
- 3/10 at 4 mL/kg bw
5/10 at 4.5 mL/kg bw
9/10 at 5 mL/kg bw - Clinical signs:
- No data
- Body weight:
- No data
- Gross pathology:
- No data
- Other findings:
- None
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Under the test conditions, oral LD50 of test substance is 4.85 g/kg bw therefore it is not classified according to the Regulation (EC) N° 1272-2008 and classified category 5 (H303) according to GHS.
- Executive summary:
In an acute oral toxicity study, 10 rats/dose were given a single oral dose of test item at 4, 4.5 and 5 mL/kg bw. Animals were then observed for mortality and clinical signs at least daily for 14 days.
3/10, 5/10 and 9/10 deads were observed at 4 mL/kg bw, 4.5 mL/kg bw and 5 mL/kg bw, respectively. The calculated LD50 was 4.33 mL/kg bw with 90% confidence limits of 4.01-4.68 mL/kg bw, corresponding to 4.85 g/kg bw and 90% confidence limits of 4.52-5.28 g/kg bw with a density of 1.1278.
Under the test conditions, oral LD50 of test substance is 4.85 g/kg bw therefore it is not classified according to the Regulation (EC) N° 1272-2008 and classified category 5 (H303) according to GHS.
Reference
None
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 020 mg/kg bw
- Quality of whole database:
- Adequate for hazard assessment
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute toxicity: via oral route
In an acute oral toxicity study, 10 rats/dose were given a single oral dose of test item at 4, 4.5 and 5 mL/kg bw. Animals were then observed for mortality and clinical signs at least daily for 14 days.
3/10, 5/10 and 9/10 deads were observed at 4 mL/kg bw, 4.5 mL/kg bw and 5 mL/kg bw, respectively. The calculated LD50 was 4.33 mL/kg bw with 90% confidence limits of 4.01-4.68 mL/kg bw, corresponding to 5.02 g/kg bw and 90% confidence limits of 4.65-5.43 g/kg bw with a density of 1.1595.
Under the test conditions, oral LD50 of test substance is 5.02 g/kg bw therefore target substance is not classified according to the Regulation (EC) N° 1272-2008 and classified category 5 (H303) according to GHS because the low limit of the 95% confidence interval is below 5 g/kg bw.
Justification for classification or non-classification
Harmonized classification:
The registered substance has no harmonized classification according to the Regulation (EC) No. 1272/2008.
Self-classification:
Acute toxicity via Oral route:
Based on the available information, the registered substance is:
- not classified according to the Regulation (EC) No. 1272/2008 and classified category 5 (H303) according to GHS because the low limit of the 95% confidence interval of the LD50 is below 5 g/kg bw.
Acute toxicity via Dermal route:This information is not available
Acute toxicity via Inhalation:This information is not available.
Specific target organ toxicity: single exposure (Oral):
The classification criteria according to the Annex VI of the Regulation (EC) No. 1272/2008 as specific target organ toxicant (STOT) – single exposure, oral are not met since no reversible or irreversible adverse health effects were observed immediately or delayed after exposure and no effects were observed at the guidance value (oral) for a Category 1 classification (C ≤ 300 mg/kg bw) and at the guidance value (oral) for a Category 2 classification (2000 mg/kg bw ≥ C > 300 mg/kg bw). No classification is required.
Specific target organ toxicity: single exposure (Dermal): This information is not available
Specific target organ toxicity: single exposure (Inhalation): This information is not available.
Based on its physical state, the registered substance is not classified for aspiration hazard.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.