Registration Dossier
Registration Dossier
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EC number: 216-251-6 | CAS number: 1533-78-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Test on the basis of H.F. Smyth et al.: Am. Ind. Hyg. Ass. J. .23, 95 - 107 (1962)
- GLP compliance:
- no
- Test type:
- other: BASF method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2'-[[3-acetamido-4-[(2-chloro-4-nitrophenyl)azo]phenyl]imino]diethyl diacetate
- EC Number:
- 216-251-6
- EC Name:
- 2,2'-[[3-acetamido-4-[(2-chloro-4-nitrophenyl)azo]phenyl]imino]diethyl diacetate
- Cas Number:
- 1533-78-4
- Molecular formula:
- C22H24ClN5O7
- IUPAC Name:
- 2,2'-[[3-acetamido-4-[(2-chloro-4-nitrophenyl)azo]phenyl]imino]diethyl diacetate
- Test material form:
- solid
- Details on test material:
- Disperse Red 167:1
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- Inhalation by means of vapor saturated at 20°C for 7 hours. To achieve saturation, air (200 L/h) was fed through an approx. 5 cm deep layer of the product.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 7 h
- Concentrations:
- saturation concentration
- No. of animals per sex per dose:
- 12 rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: daily observation, weekly weighing
- Necropsy of survivors performed: yes - Statistics:
- NA
Results and discussion
- Preliminary study:
- NA
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC0
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: no effect on saturation concentration
- Mortality:
- no deaths
- Clinical signs:
- other: no effects
- Body weight:
- no data
- Gross pathology:
- no effects
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this acute inhalation study, 7 hours inhalation of the volatile constituents of the test material did not lead to any deaths in rats (0/12).
- Executive summary:
In an acute inhalation toxicity study, 12 rats were exposed by inhalation route to the volatile constituents of the test material in a saturation concentration for 7 hours. Animals were then observed for 7 days.
No deaths occurred and no clinical signs as well as gross pathology signs were observed.
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