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Ecotoxicological information

Short-term toxicity to fish

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Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, and documentation / justification is limited
Justification for type of information:
QSAR prediction
Guideline:
other: REACH Guidance on (Q)SAR
Principles of method if other than guideline:
(Q)SAR
Test organisms (species):
no data
Test type:
other: (Q)SAR
Water media type:
freshwater
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
0.192 mg/L
Sublethal observations / clinical signs:

ECOSAR Program (v1.11) Results:

See attachment in above summary: Aquatic toxicity - ECOSAR Program (v1.11) Results

Validity criteria fulfilled:
no
Remarks:
Neutral Organic SAR: Maximum LogKow: 5.0 (Fish LC50 96h)
Conclusions:
Not conclusive: Validity criteria not fullfilled
Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction
Guideline:
other: REACH Guidance on (Q)SAR
Principles of method if other than guideline:
(Q)SAR
Test organisms (species):
no data
Test type:
other: (Q)SAR
Water media type:
freshwater
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
0.328 mg/L
Sublethal observations / clinical signs:

ECOSAR Program (v1.11) Results:

See attachment in above summary: Aquatic toxicity - ECOSAR Program (v1.11) Results

Validity criteria fulfilled:
yes
Remarks:
Aliphatic Amines: Maximum LogKow: 6.0 (Fish LC50 96h)
Conclusions:
Estimated LC50 (96 h) : 0.32 mg/L
Intermediate substance is estimated to be very toxic to fish (acute toxicity).

Description of key information

ECOSAR 1.11: Fish: LC50 (96h): 0.328 mg/L

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.32 mg/L

Additional information

Intermediate substance is estimated to be very toxic to fish (acute toxicity).