Hexakis[μ-(acetato-O:O')]-μ3-oxo-triangulo-triruthenium acetate

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)

Deviations:

not specified

Principles of method if other than guideline:

A screening test was conducted where the sample was sieved through a 100 µm sieve for approximately 10 minutes and the mass of test material passing through the sieve was measured. For the definitive test, a cascade impactor was used to determine particle size. Too few particles with a size less than 10 µm were present to allow accurate assessment of mass median aerodynamic diameter.

GLP compliance:

yes (incl. QA statement)

Type of method:

cascade impaction

Type of distribution:

other: Particle size distribution, fibre length and diameter distribution

No.:

#1

Size:

< 100 µm

Distribution:

12.56 %

No.:

#2

Size:

< 10 µm

Distribution:

2.56 %

12.5% of the test material had a particle size < 100 µm. 2.56% of the test material had a particle size < 10 µm.

Conclusions:

12.5% of the test material had a particle size <100 µm. 2.56% of the test material had a particle size <10 µm. it was determined that too few particles were of a size <10 µm to allow accurate assessment of mass median aerodynamic diameter.

Executive summary:

This is a GLP compliant, guideline study considered suitable for use as the key study for this endpoint.12.5% of the test material had a particle size <100 µm. 2.56% of the test material had a particle size <10 µm. it was determined that too few particles were of a size <10 µm to allow accurate assessment of mass median aerodynamic diameter. 

Description of key information

12.5% of the test material had a particle size <100 µm. 2.56% of the test material had a particle size <10 µm. It was determined that too few particles were of a size <10 µm to allow accurate assessment of mass median aerodynamic diameter.  

Additional information

Woolley and Mullee (2004) is a GLP compliant study following OECD TG 110 and is considered suitable for use as the key study for this endpoint.12.5% of the test material had a particle size <100 µm. 2.56% of the test material had a particle size <10 µm. it was determined that too few particles were of a size <10 µm to allow accurate assessment of mass median aerodynamic diameter.