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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
January from 02nd to 13th, 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
Adopted: 27 July 1995
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Water solubility:
5.58 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
9
Details on results:
MAIN TEST
The solubility of test item in milli-Q water was determined to be 5.55 g/l, 5.56 g/l and 5.62 g/l for replicates Flask 1 (24 Hours), Flask 2 (48 Hours) and Flask 3 (72 Hours) respectively. The mean water solubility was 5.58 g/l with 0.68 % RSD at 20 °C by shake flask method within the limit of 15 % for three time points.

PRELIMINARY TEST
Preliminary result indicated that the test item had a solubility of more than 10^-2 g/l in milli-Q water.

Summary of results

Day Test item content (g/l) pH
24 hours 5.55 9.0
48 hours 5.56 9.0
72 hours 5.62 9.0
Average 5.58 9.0
SD 0.038 0
% RSD 0.68 -

Sample Code Sample Peak Area  Slope  Intercept Standard Conc. Dilution Factor Conc. obtained (g/l) Mean conc. obtained (g/l) ± SD % RSD

At 24 hours
Sample Flask 1 R1-Rep 1 264495 587590 3900.6 0.41 12500 5.54 5.55 0.01 0.18
Sample Flask 1 R1-Rep 2 265047 0.41 12500 5.56
Sample Flask 1 R2-Rep 1 264603 0.41 12500 5.55
Sample Flask 1 R2-Rep 2 264630 0.41 12500 5.55

At 48 hours
Sample Flask 2 R1-Rep 1 264921 590816 2595.43 0.41 12500 5.55 5.56 0.02 0.36
Sample Flask 2 R1-Rep 2 266426 0.41 12500 5.58
Sample Flask 2 R2-Rep 1 264943 0.41 12500 5.55
Sample Flask 2 R2-Rep 2 265918 0.41 12500 5.57

At 72 hours
Sample Flask 3 R1-Rep 1 267936 589419 2924.87 0.41 12500 5.62 5.62 0.02 0.36
Sample Flask 3 R1-Rep 2 268215 0.41 12500 5.63
Sample Flask 3 R2-Rep 1 266461 0.41 12500 5.59
Sample Flask 3 R2-Rep 2 267765 0.41 12500 5.62
Conclusions:
Water solubility: 5.58 g/l at 20 °C and pH 9.0
Executive summary:

The water solubility of the test item was determiend by flask method, in accordance to the procedures outlined into the OECD guideline 105.

A preliminary test was conducted to determine the solubility of test item in milli-Q water and the solubility resulted to be more than 10^-2 g/l. Accordingly, definitive study was conducted by shake flask method.

Three separate flasks were prepared. For analytical determination of the subtance, the HPLC-UV method was validated.

The solubility of test item in milli-Q water was determined to be 5.55 g/l, 5.56 g/l and 5.62 g/l for replicates Flask 1 (24 Hours), Flask 2 (48 Hours) and Flask 3 (72 Hours) respectively. The mean water solubility was 5.58 g/l with 0.68 % RSD at 20 °C and pH 9.0 by Shake flask method within the limit of 15 % for three time points.

Conclusion

Water solubility: 5.58 g/l at 20 °C and pH 9.0

Description of key information

Water solubility: 5.58 g/l at 20 °C and pH 9.0

Key value for chemical safety assessment

Water solubility:
5.58 g/L
at the temperature of:
20 °C

Additional information

OECD105 - flask method