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Physical & Chemical properties

Water solubility

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Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
Not reported
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
Cited as Directive 92/69/EEC, A.6
GLP compliance:
yes
Type of method:
flask method
Water solubility:
4.419 g/L
Temp.:
20.1 °C
pH:
9
Remarks on result:
other: The typical pH value of the samples was 7.6
Water solubility:
1.695 g/L
Temp.:
20.1 °C
pH:
7
Remarks on result:
other: The typical pH value of the samples was 6.9
Water solubility:
1.108 g/L
Temp.:
20.1 °C
Remarks on result:
other: Unadjusted distilled water. The typical pH value of the samples was 5.0
Details on results:
pH effects: Unadjusted, pH 7 and pH 9 were tested.
Conclusions:
The water solubility was determined in unadjusted distilled water, pH 7 buffer and pH 9 buffer. The results were 1.108 g/L at 20.1°C, 1.695 g/L at 20.1°C and 4.419 g/L at 20.1°C respectively.
Executive summary:

Unadjusted distilled water:

1.108 g/L at 20.1°C.

Distilled water buffered at pH 7:

1.695 g/L at 20.1°C.

Distilled water buffered at pH 9:

4.419 g/L at 20.1°C.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 January 2000 to 17 March 2000
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
Cited as Directive 92/69/EEC, A.6
GLP compliance:
yes
Type of method:
flask method
Water solubility:
1 153 mg/L
Temp.:
20 °C
Remarks on result:
other: Distilled water
Water solubility:
810 mg/L
Temp.:
10 °C
pH:
5
Water solubility:
1 113 mg/L
Temp.:
20 °C
pH:
5
Water solubility:
1 631 mg/L
Temp.:
30 °C
pH:
5
Water solubility:
1 301 mg/L
Temp.:
10 °C
pH:
7
Water solubility:
1 707 mg/L
Temp.:
20 °C
pH:
7
Water solubility:
2 438 mg/L
Temp.:
30 °C
pH:
7
Water solubility:
3 181 mg/L
Temp.:
10 °C
pH:
9
Water solubility:
3 628 mg/L
Temp.:
20 °C
pH:
9
Water solubility:
4 220 mg/L
Temp.:
30 °C
pH:
9
Details on results:
Temperature effects: Temperature range of 10 °C to 30 °C
Conclusions:
The water solubility was determined in distilled water at 20°C and pH 5.0, 7.0 and 9.0 aqueous buffer at 10, 20 and 30°C.
The water solubility in distilled water was determined to be 1153 mg/L at 20°C
Executive summary:

The water solubility in distilled water was determined to be 1153 mg/L at 20°C

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 September 1998 to 19 November 1998
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
Cited as Directive 92/69/EEC, A.6
GLP compliance:
yes
Type of method:
flask method
Key result
Water solubility:
1 085 mg/L
Conc. based on:
test mat.
Incubation duration:
ca. 24 h
Temp.:
20 °C
pH:
ca. 4.5
Remarks on result:
other: The mixtures were centrifuged and filtered prior to dilution and HPLC determination
The water solubility of BIT was determined to be 1.085 g/L with a relative standard  deviation of 0.92%.
Conclusions:
The water solubility of BIT was determined to be 1085 mg/L with a relative standard deviation of 0.92%.
Executive summary:

The water solubility of BIT was determined to be 1085 mg/L.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25 February 2002 to 22 March 2002
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
Cited as Directive 92/69/EEC, A.6
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Key result
Water solubility:
0.727 g/L
Temp.:
10 °C
pH:
4.8
Key result
Water solubility:
0.938 g/L
Temp.:
20 °C
pH:
4.8
Key result
Water solubility:
1.196 g/L
Temp.:
30 °C
pH:
4.8
Key result
Water solubility:
1.288 g/L
Temp.:
20 °C
pH:
6.7
Key result
Water solubility:
1.651 g/L
Temp.:
20 °C
pH:
9.1
Conclusions:
The solubility of BIT over the pH range 4.8 to 9.1 (at 20°C) and temperature range 10 - 30°C (at pH 4.8) increased from 0.938 to 1.651 g/l and 0.727 to 1.196 g/l respectively.
Executive summary:

The water solubility of BIT was 0.727, 0.938, and 1.196 g/l at 10, 20 and  30°C, respectively (pH 4.8).

The water solubility of BIT was 0.938, 1.288, and 1.651 g/l at pH 4.8,  6.7 and 9.1, respectively (20°C).

Description of key information

The water solubility was determined according to EU Method A.6 (Seal, 2002).

Key value for chemical safety assessment

Water solubility:
1 288 mg/L
at the temperature of:
20 °C

Additional information

The water solubility value was measured at pH 6.7.