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EC number: 255-527-0 | CAS number: 41741-86-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978-03-15 to 1978-03-29
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Sodium bis[2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)]chromate(1-)
- EC Number:
- 255-527-0
- EC Name:
- Sodium bis[2-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]benzoato(2-)]chromate(1-)
- Cas Number:
- 41741-86-0
- Molecular formula:
- C34 H24 Cr N8 O6 .Na
- IUPAC Name:
- Sodium;chromium(3+);2-[(3-methyl-5-oxido-1-phenylpyrazol-4-yl)diazenyl]benzoate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Diet: ad libitum, HERILAN MRH-Haltung (single diet for housing of mice, rats and hamsters) from Heinrich EGGERSMANN KG, Rinteln
- Weight at study initiation (all concentrations): 30 g (males), 24 g (females)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- Suspension in 0.5 % aqueous CMC.
Test concentrations used: 2, 7 and 20 % - Doses:
- 200, 700, 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
* Observations done from <1hour until 14 days after application
* Weighting at start of trial and on days 2, 7 and 13 (2000 mg/kg dose); at start of trial and on days 1, 7 and 13 (700 and 200 mg/kg dose)
- Necropsy of survivors performed: yes (on day 14)
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- At 2000 mg/kg two of five male mice died within 15 minutes after application
- Clinical signs:
- Short-termed deteriorated general state; time of deaths within 15 minutes; unspecific symptoms (dyspnoea, apathy, stagger, tremor)
- Body weight:
- Initial body weight stagnation
- Gross pathology:
- Animals that died (2 males): intra-abdominal substance residues
Sacrificed animals: intra-abdominal substance residues (200 and 700 mg/kg) and intra-abdominal substance incorporations (2000 mg/kg)
Any other information on results incl. tables
Weight development during test:
Mean body weight of mice during trial (2000 mg/kg):
- Day 2: 90 g (3 males), 120 g (5 females)
- Day 13: 112 g (3 males), 142 g (5 females)
Mean body weight of mice during trial (700 mg/kg):
- Day 1: 155 g (5 males), 118 g (5 females)
- Day 13: 188 g (5 males), 140 g (5 females)
Mean body weight of mice during trial (200 mg/kg):
- Day 2: 166 g (5 males), 127 g (5 females)
- Day 13: 193 g (5 males), 136 g (5 females)
Further detection of clinical symptoms:
2000 mg/kg application:
- clear symptoms of irregular respiration up to 5 hours after
application and sporadically clear symptoms 1 day after application
- clear to strong symptoms of tremor up to 30 minutes after
application
- clear symptoms of convulsion up to 15 minutes after application
- poorly developed signs of bad general condition up to 30 minutes
after application, but good condition afterwards until end of the test
700 mg/kg application:
- poor signs of irregular respiration, apathy and tremor at 30 min
and 2 hours after application, after 4 hours sporadically poor signs
- sporadically poor symptoms on skin and fur after 4 hours
- good general condition during test, except of 30 min, 2 and 4
hours after application (partly poor signs of bad general condition)
200 mg/kg application:
- poor signs of irregular respiration, apathy, tremor and poor
symptoms on skin and fur at 1 day after application
- good general condition during test, except of day 1 (partly poor signs
of bad general condition)
Applicant's summary and conclusion
- Conclusions:
- LD50 (male/female) of >2000 mg/kg
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