Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-675-9 | CAS number: 98-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The elimination of [methyl-14C]p-tert-butyltoluene (purity not given) after intragastric and inhalational administration (doses of 100 mg/kg) was studied in male Wistar rats and in male Dunkin Hartley guinea pigs (Ingebritson and Walde, 1982; Walde and Scheline, 1983).
The chemical was well absorbed through the gastro-intestinal and respiratory tract, was quickly distributed, and was eliminated within a few days.
In rats, 73% of a single oral dose (100 mg/kg) was recovered in the urine and feces within 3 days. After 10 days, 83% of the administered dose was recovered; the ratio of urinary/fecal radioactivity was ca. 3.5 : 1. Elimination was biphasic with the slower elimination phase beginning on day 6 after dosing.
At day 3 after dosing, urinary excretion of radioactivity was 45% and 25% after oral and inhalational exposure, respectively, in rats and 42% and 41% after oral and inhalational administration, respectively, in guinea pigs.
In a metabolism study (Roche 1982), p-tert-butyltoluene (purity not given) was administered orally to rats at dose levels of 0, 25, and 100 mg/kg bw. Urine was collected within 24 h after dosing, worked up and analyzed by GC and GC/MS.
p-Tert-butylbenzoic acid (TBBA) was detected in a dose-related way in the urine samples of all treated rats. However, the corresponding p-tert-butyl hippuric acid (TBHA; i.e. the glycine conjugate of TBBA) could not be detected. GC/MS revealed additional peaks which were tentatively assigned to the trimethylsilyl derivatives of p-tert-hydroxybutylbenzoic acid and p-tert-carboxybutylbenzoic acid. These results suggested that p-tert-butyltoluene was metabolized by rats to a considerable degree to TBBA, which was eliminated in the urine (probably as glucuronide). Minor amounts of TBBA were further oxidized at the tertiary butyl group and then excreted in the urine. The oxidation reaction was likely to be a result of microsomal enzymes in the liver.
The following metabolic pathway was proposed: tert-butyl toluene is oxidized to p-tert-butyl benzoic acid and, in parts, further oxidized to p-tert-hydroxybutyl benzoic acid. The two latter compounds and are excreted in the urine, probably as glucuronides.
This metabolism study in the rat is classified acceptable and satisfies the guideline requirement for a metabolism study in rats.
On the occasion of various 5 day oral toxicity studies of TBT, mice, guinea pigs and dogs were administered 100 mg/kg bw/d TBT for 5 days, and urine was collected for 24 h after the last administration and analyzed for the different metabolites, i.e. TBBA and TBHA by GC analysis. TBBA was determined as metabolite in urine samples of treated dogs and at very low amounts in guinea pigs. However, TBHA was found to be at higher levels in urine samples of treated mice and guinea pigs compared to TBBA, whereas TBHA levels were lower in the urine of dogs than TBBA levels
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.