Benzofuran-2-yl methyl ketone

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

27 February to 3 March 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

1995

GLP compliance:

yes (incl. QA statement)

Remarks:

Swiss Federal Office of Public Health, Bern, Switzerland

Type of method:

flask method

Key result

Water solubility:

453 mg/L

Incubation duration:

>= 24 - <= 72 h

Temp.:

20 °C

pH:

ca. 7.1

The R² fit of the calibration curve used was 0.9993. This reflects the linearity of the analytical system within the calibration range of 30.0 to 120 mg test item /L. The calibration was verified by a 2nd weighing of the test item and dilution of this stock solution into the calibration curve at levels of 41.7, 62.5 and 104 mg/L. Analysis of these quality control solutions and evaluation against the calibration curve yielded recoveries of 104%, 102% and 102% compared to the nominal values. These data show the correct preparation of the calibration standards.

 

The following table summarizes the results of the water solubility test. The tabulated values represent rounded results, obtained by calculation using the exact raw data.

 

Sample No.	Shaking time at 30 °C	Determined concentration	Water Solubility Mean Value	Overall Mean ± Std. Dev.	Rel. Std. Dev.
	[hours]	[mg/L]	[mg/L]	[mg/L]	[%]
72-7	72	440	447	453 ± 6	1
72-8	72	453
48-7	48	452	453
48-8	48	454
24-7	24	459	460
24-8	24	460

 

According to the test guideline, the results for three assays should not differ by more than 15% for three assays. The acceptance criterium was fulfilled. Thus, the study is valid.

 

The test item showed to be stable during the performance of the test.

 

A mean pH value of 7.1 was measured for the used solutions.

 

The water solubility of the test substance was found to be 453 ± 6 mg/L.

Conclusions:

A water solubility value of 453 ± 6 mg/L (at 20 °C, pH ca. 7.1) was determined for the test substance according to OECD 105.

Description of key information

Water solubility: 453 ± 6 mg/L at 20 °C, pH ca. 7.1 (OECD Guideline 106, flask method)

Key value for chemical safety assessment

Water solubility:

453 mg/L

at the temperature of:

20 °C