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EC number: 209-506-8 | CAS number: 583-52-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral (no guideline followed), rat: LD50 = 375 mg/kg bw (female)
(RA from CAS 144-62-7)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- (no details on test animals and environmental conditions were given
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single oral dose toxicity was usually determined by the method of Smyth et al. (1962) in which the LD50 and its 95% confidence limits are estimated by the moving average technique (Thompson, 1947; Weil, 1952). Occasionally enough data were obtained to use the probit method (Finney, 197 1) for calculation.
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200 - 300 g
- Diet: Purina Formulab Chow 5008 - Route of administration:
- oral: unspecified
- Vehicle:
- water
- Control animals:
- not specified
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 7.5 mL/kg bw
- Based on:
- test mat.
- Remarks:
- 5% (w/v) in aqueous solution
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 9.5 mL/kg bw
- Based on:
- test mat.
- Remarks:
- 5% (w/v) in aqueous solution
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 375 mg/kg bw
- Based on:
- test mat.
- Remarks:
- 100% by calculation
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 475 mg/kg bw
- Based on:
- test mat.
- Remarks:
- 100% by calculation
- Interpretation of results:
- other: Category 4 based on CLP/EU GHS criteria, according to Regulation (EC) No 1272/2008
- Conclusions:
- CLP: Acute Oral 4, H302 (Annex VI harmonized classification)
The available data on acute toxicity (oral) are in consistency with the harmonized classification according to Regulation (EC) 1272/2008, Annex VI. - Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Please refer to analogue justification provided in IUCLID section 13
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 375 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Source, Vernot et al., 1977
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 475 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Source, Vernot et al., 1977
- Interpretation of results:
- other: Category 4 based on CLP/EU GHS criteria, according to Regulation (EC) No 1272/2008
- Conclusions:
- CLP: Acute toxicity, Cat. 4, H302 (Annex VI harmonized classification)
The available data on acute toxicity (oral) of the source substance are in consistency with the harmonized classification according to Regulation (EC) 1272/2008, Annex VI (Index No. 607-006-00-8).
Applying the RA-A approach and in consistency with the harmonized classification of the target substance according to Regulation (EC) 1272/2008, Annex VI (Index No. 607-007-00-3), the target substance meets the criteria for classification as Acute Tox. Cat. 4, oral, H302.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 375 mg/kg bw
- Quality of whole database:
- The available information comprises an adequate and reliable study (Klimisch score 2) from a reference substance with similar structure and intrinsic properties. Read-across is justified based on structural similarity and similarities in physico-chemical properties. The selected studies are thus sufficient to fulfil the standard information requirements set out in Annex VII, 8.5, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for read-across
There are no reliable data available regarding acute toxicity for either dipotassium oxalate monohydrate (CAS 6487-48-5) or dipotassium oxalate anhydrate (CAS 583-52-8). Read-across from an appropriate substance (oxalic acid (CAS 144-62-7) is conducted in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. in order to fulfil the standard data requirements defined in Regulation (EC) No 1907/2006, Annex VII, 8.5. Common functional groups, structural similarities and comparable toxicological properties (according to the joint consideration in Annex VI to CLP) of the source and target substance are the basis of read-across. A detailed justification for the analogue read-across approach is provided in the technical dossier (see IUCLID Section 13).
Acute oral toxicity
CAS 144-62-7
Acute toxicity of oxalic acid was tested in male and female rats (Vernot et al., 1977). In this publication acute toxicity data for some organic and inorganic compounds and aqueous solutions (among them 5% (w/v) oxalic acid) were tested. The test substance 5% (w/v) aqueous solution of oxalic acid was orally administered. Based on the result of this study, a LD50 of 375 and 475 mg/kg bw was derived for females and males, respectively.
A poisoning incident was described by Umezum (1980). A Japanese 26-year old woman took 30 g of oxalic acid. 10 hours after hospitalisation, the patient died. The patient complained about a burning sensation in the throat, dizziness, diarrhoea and cold sweat as well as shock symptom (no further details were given in the report). Following examination, corrosion of the tongue, inflammation of the esophagus, atony and inflammation of the stomach, and black digested material in stomach and small intestine was observed (please refer to 7.10.3).
Justification for classification or non-classification
According to Article 13 of Regulation (EC) No. 1907/2006 "General Requirements for Generation of Information on Intrinsic Properties of substances", information on intrinsic properties of substances may be generated by means other than tests e.g. from information from structurally related substances (grouping or read-across), provided that conditions set out in Annex XI are met. Annex XI, "General rules for adaptation of this standard testing regime set out in Annexes VII to X” states that “substances whose physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity may be considered as a group, or ‘category’ of substances. This avoids the need to test every substance for every endpoint". Since the analogue concept is applied to dipotassium oxalate, data will be generated from information on reference source substance(s) to avoid unnecessary animal testing. Additionally, once the analogue read-across concept is applied, substances will be classified and labelled on this basis.
Applying the RA-A approach and in consistency with the harmonized classification of the target substance according to Regulation (EC) 1272/2008, Annex VI (Index No. 607-007-00-3), the target substance dipotassium oxalate meets the criteria for classification as Acute oral Tox. Cat. 4, H302 and Acute dermal Tox., Cat. 4, H312.
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