Reaction products of propane-1,2-diamine with 2-[(2-methylphenoxy)methyl]oxirane

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2017-11-29 to 2018-06-26

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

see 'Principles of method if other than guideline'

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

yes

Remarks:

see 'Principles of method if other than guideline'

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Deviations:

yes

Remarks:

see 'Principles of method if other than guideline'

Principles of method if other than guideline:

A miscibility test was carried out to evaluate the solubility of Test Item in water. This procedure deviates from the guideline but is considered scientifically valid.

GLP compliance:

yes (incl. QA statement)

Type of method:

other: miscibility test with visual inspection

Key result

Conc. based on:

test mat.

Temp.:

20 °C

pH:

>= 11.18 - <= 11.69

Remarks on result:

other: miscible with water above a ratio of 50:50 (w/w)

Details on results:

The test item is miscible with water above a ratio of 50:50 (w/w). There are two phases observed at a ratio of 1:9 test item : water but no saturated solution could be prepared as the addition of more test item results in a homogeneous single phase system.

Table 1. Water solubility test

Test Item, (g)	Water, (g)	Observation	Observation (after 10 minutes)	pH value
0.5006	4.5208	opalescent, single-phase liquid	two separate phases	11.25
0.5071	4.5020	opalescent, single-phase liquid	two separate phases	11.18
2.0166	2.0188	clear, single-phase liquid	clear, single-phase liquid	11.39
2.0053	2.0039	clear, single-phase liquid	clear, single-phase liquid	11.50
4.5088	0.5092	clear, single-phase liquid	clear, single-phase liquid	11.65
4.5098	0.5164	clear, single-phase liquid	clear, single-phase liquid	11.69

 

Conclusions:

The test item is miscible with water above a ratio of 50:50 (w/w) at ambient temperature.

Executive summary:

The water solubility was determined according to OECD 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840. In a preliminary test no saturated solution of the test item could be prepared, therefore, the standard methods for determination of the water solubility are technically not feasible. Therefore, the water solubility of the test item was determined using the miscibility test with visual detection. The test item was mixed with ultrapure water in rations 1 :1, 1 : 9 and 9 : 1. After sonication and vigorous chaking the solubility was visually detected. The pH of each sample was recorded. The test substance was determined to be miscible with water above a ratio of 50:50 (w/w) at ambient temperature. There are two phases observed at a ratio of 1:9 test item : water, still, no saturated solution could be prepared as the addition of more test item results in a homogeneous single phase system.

Description of key information

The test item is miscible with water above a ratio of 50:50 (w/w) at ambient temperature.

Additional information

The water solubility was determined according to OECD 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840. In a preliminary test no saturated solution of the test item could be prepared, therefore, the standard methods for determination of the water solubility are technically not feasible. Therefore, the water solubility of the test item was determined using the miscibility test with visual detection. The test item was mixed with ultrapure water in rations 1 :1, 1 : 9 and 9 : 1. After sonication and vigorous chaking the solubility was visually detected. The pH of each sample was recorded. The test substance was determined to be miscible with water above a ratio of 50:50 (w/w) at ambient temperature. There are two phases observed at a ratio of 1:9 test item : water, still, no saturated solution could be prepared as the addition of more test item results in a homogeneous single phase system.