Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 908-998-8 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Feb 1966
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study design similar to OECD 401; summary report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- 7 days observation period, females tested
- GLP compliance:
- no
- Remarks:
- performed before GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- (propan-2-yloxy)phosphonic acid; phosphoric acid; propan-2-ol
- EC Number:
- 908-998-8
- Molecular formula:
- can not be determined for reaction masses
- IUPAC Name:
- (propan-2-yloxy)phosphonic acid; phosphoric acid; propan-2-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: 12 h
- Diet (e.g. ad libitum): Standard Altromin R (Altrogge, Lage/Lippe, Germany), ad libitum
- Water (e.g. ad libitum): tap water. ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- concentration in vehicle: 10 %
- Doses:
- Reinigerkomponente MI - normal:
1.6; 2.5; 4.0 or 6.3 mL/100 g bw - No. of animals per sex per dose:
- 10 females/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Statistics:
- no data
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3.85 other: mL (10% solution)/100 g
- 95% CL:
- > 3.75 - <= 4
- Mortality:
- Dose: 1.6 mL (10% solution)/100 g, Mortality rate: 0 / 10
Dose: 2.5 mL (10% solution)/100 g, Mortality rate: 0 / 10
Dose: 4.0 mL (10% solution)/100 g, Mortality rate: 7 / 10
Dose: 6.3 mL (10% solution)/100 g, Mortality rate: 10 / 10 - Clinical signs:
- other: no data
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Conclusions:
- The median lethal dose of the testsubstance was 3.85 mL/100 g body weight.
- Executive summary:
The test item was tested for its acute oral toxicity potential. 10 female rats were treated with doses of 1.6, 2.5, 4.0 or 6.3 mL (10% solution)/100 g bw and observed for 7 days.
The median lethal dose was 3.78 mL (10% solution)/100 g bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
