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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs on Cinnamyl Nitrile.
Author:
D. L. J. Opdyke
Year:
1976
Bibliographic source:
Food and Cosmetics Toxicology, Volume 14, Supplement, 1976, Pages 721-722

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To evaluate skin irritation potential of Cinnamonitrile on human subjects.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Cinnamonitrile
EC Number:
217-552-5
EC Name:
Cinnamonitrile
Cas Number:
1885-38-7
Molecular formula:
C9H7N
IUPAC Name:
cinnamonitrile
Test material form:
liquid
Details on test material:
- Name of test material: Cinnamonitrile
- IUPAC name: (E)-3-phenylprop-2-enenitrile
- Molecular formula: C9H7N
- Molecular weight: 129.161 g/mole
- Smiles : N#C\C=C\c1ccccc1
- Inchl: 1S/C9H7N/c10-8-4-7-9-5-2-1-3-6-9/h1-7H/b7-4+
- Substance type: Organic
- Physical state: Liquid (colorless-yellow)
Specific details on test material used for the study:
IUPAC: Cinnamonitrile
CAS No:1885-38-7
EC No: 217-552-5
Commen name: Cinnamyl Nitrile
Molecular formula : C9H7N
Molecular weight : 129.161 g/mol
substance type: organic
InChI: 1S/C9H7N/c10-8-4-7-9-5-2-1-3-6-9/h1-7H/b7-4+
Smiles :N#C\C=C\c1ccccc1
Physical state: colorless- yellow liquid

In vitro test system

Details on test system:
No data available

Test animals

Species:
other: Human
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: petrolatum
Controls:
not specified
Amount / concentration applied:
4% in petrolatum
Duration of treatment / exposure:
48 hrs
Observation period:
48 hrs
Number of animals:
Not specified
Details on study design:
Not specified

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No dermal reaction was observed on human skin

Applicant's summary and conclusion

Interpretation of results:
other: Not irritant
Conclusions:
Cinnamyl nitrile did not resulted any skin reaction when tested on human subjects. Hence, Cinnamyl nitrile can be considered as not irritation on human skin.
Executive summary:

Cinnamyl nitrile was used as a test material to evaluate its skin irritation potential on human subjects by closed patch test.

It was applied in the concentration of 4% in petrolatum for 48 hrs in a closed patch test produced no skin reaction.

 Cinnamyl nitrile did not resulted any skin reaction when tested on human subjects. Hence, Cinnamyl nitrile can be considered to be not irritation on human skin.