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EC number: 202-864-6 | CAS number: 100-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test item showed no inhibition effect to the aquatic organisms relevant for classificatiob. The EC50 at 48 hours with Daphnia magna was determined to be 676 mg/L. The EC50 and EC10 based on growth rate to the green algae Raphidocelis subcapitata, were >100 mg/L and 12 mg/L, respectively.
Additional information
Shrot-term toxicity to invertebrates
In the acute immobilisation test (reference 6.1.3-1) with Daphnia magna (STRAUS), the effects of the test item were determined according to Methods of Testing New Chemical Substances <Algal Growth Inhibition Test, Daphnia Acute Immobilization Test, and Fish Acute Toxicity Test> (Nov 21, 2003; No.1121002, Pharmaceutical and Food safety bureau, ministry of health, laour and welfare; Nov 13, 2003, No.2, Manufacturing industries bureau, Ministry of Economy, trade and industry; No. 031121002).The study was conducted in a static system over a period of 48 hours with nominal concentrations 20, 43, 93, 200, 430, 930, 2000 mg/L. The validity criteria of the test guideline were fulfilled. The estimated EC50 value (48 hours) of the test item is 676 mg/L.
Toxicity to aquatic algae
The effect of the test item on the growth of a unicellular green algal species Raphidocelis subcapitata was determined according to OECD 201, Regulation (EC) No. 226/2016 Method C.3 and EPA OPPTS 850.5400 and under GLP (reference 6.1.5-1). The study was conducted under static conditions with an initial cell density of 1x104 cells/mL for a period of 72 hours. A stock solution of 100 mg/L was freshly prepared with OECD Medium and shaken until the test item was completely dissolved. Six concentrations were tested in a geometrical series with a dilution factor of 3 (nominal): 0.4 - 1.2 - 3.7 - 11.1 - 33.3 - 100 mg/L. The measured concentrations of the test item in the fresh media (0 h) were in the range of 98 to 100 % of the nominal values and in the old media (72 h) were in the range of 71 to 94 % of the nominal values of all concentrations. The measured concentrations deviated more than 20 % from the nominal in the two lowest concentrations at the end of the test, therefore, the geometric mean of the measured start and end concentrations was calculated to determine exposure concentrations. The EC50-values for inhibition of growth rate (ErC50) was >100 mg/L and for inhibition of yield (EyC50) was 33.1 mg/L. The EC10 value with 95% confidence interval was determined to be 12.0 mg/L (7.7 – 18.5 mg/L) based on growth rate (ErC10) and 0.22 mg/L (0.04 - 0.58 mg/L) based on yield (EyC10).
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