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EC number: 249-682-3 | CAS number: 29529-99-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 6-(dibutylamino)-1,3,5-triazine-2,4(1H,3H)-dithione
- EC Number:
- 249-682-3
- EC Name:
- 6-(dibutylamino)-1,3,5-triazine-2,4(1H,3H)-dithione
- Cas Number:
- 29529-99-5
- Molecular formula:
- C11H20N4S2
- IUPAC Name:
- 6-(dibutylamino)-1,3,5-triazine-2,4(1H,3H)-dithione
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 2000, 300, 50, and
5 mg/kg. Since no animal died in the first-administration group at the starting dose of 300 mg/kg, the
second-administration group received the samc dose. After confirming no animal dicd after thc second
administration, the third-administration group received the 2000-mg/k.g dose. Since no animal died
after the third administration, the fourth-administration group received the 2000-mg/kg dose again - No. of animals per sex per dose:
- 3
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No death occurred in any of the groups at the dose of 300 or 2000 mg/kg, and the LD50 is greater
than 2000 mg/kg. - Clinical signs:
- other: (I) 300-mg/kg dose [1] First-administration group No abnormalities were noted in thc appearance or behavior. [2] Second-administration group No abnormalities were noted in the appearance or behavior. (2) 2000-mg/kg dose [1] Third-administration group One
- Gross pathology:
- (1) 300-mglkg dose
[1] First-administration group
Macroscopic observation revealed no abnormalities in color or configuration of the surface,
orifice, or argans or lymph nodes in the cranial, thoracic, or abdominal cavity.
[2] Second-administration group
Macroscopic observation revealed no abnormalities in color or configuration of the surface,
orifice, or argans or lymph nodes in the cranial, thoracic, or abdominal cavity.
(2) 2000-mglk:g dose
[l] Third-administration group
Macroscopic Observation revealed no abnormalities in color or configuration of the surface,
orifice, ar argans ar lymph nodes in the cranial, thoracic, ar abdominal cavity.
[2] Fourth administration (2000-mglkg dosc)
Macroscopic observation revealed no abnormalities in color or configuration of the surface,
orifice, ar argans or lymph nodes in the cranial, thoracic, ar abdominal cavity.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The acute toxicity of a single oral dose of Actar BSH was investigated in rats.
Twclve female SLC:Wistar rats were used in 4 groups consisting of 3.
The test substance is a white powder, and the dosing formulations were prepared with watcr for
injection as the vehicle.
As the test method, the acute toxic class mcthod was employed with doses of 2000, 300, 50, and
5 mglkg. Since no animal died in the first-administration group at thc starting dosc of 300 mg/kg, the
second-administration group received the samc dosc. After confirming no animal died after the second
administration, the third-administration group receivcd thc 2000-mglkg dose. Since no animal died
after the third administration, the fourth-administration group rcceived thc 2000-mglkg dose again. For
administration, singlc oral gavage with a metal starnach tube was selected. Observation of mortality
and general condition was performed far 14 days after administration.
As results, in the first- and second-administration groups at the dose of 300 mglk:g, no animal died,
and no abnormalities werc noted in appearance or behavior in gcncral-condition observation or necropsy. The body weights satisfactorily increased for 14 days. At 2000 mg/kg, 1 animal in the
third-administration group showed slowness in behavior followcd by abnormal gait; these signs
recovcred by after 2 hours. In the other 2 animals of the group and the ones in the
fourth-administration group, no abnormalities were noted in appearance or behavior in
gencral-condition observation. The body weights of all the animals reccived the 2000-mg/kg dose
satisfactorily increased for 14 days, and necropsy revealed no abnormalities at the dose.
Based on the abovc results, the test substance induced toxicity at the dose of 2000 mg/k:g, but not
lcthal. In conclusion, the LD50 is greater than 2000 mglkg, and it should be classifi.ed in Class5 in GHS
Classification. - Executive summary:
The acute toxicity of a single oral dose of Actor BSH was investigated in rats.
Twelve femalc SLC:Wistar rats were used in 4 groups consisting of 3.
The test substance is a white powder, and the dosing formulations were prepared with water for
injection as the vehicle.
As the test mcthod, the acute toxic class mcthod was employed with doses of 2000, 300, 50, and
5 mg/kg. Since no animal died in the first-administration group at the starting dose of 300 mg/kg, the
second-administration group received the same dose. After confirming no animal died after the second
administration, the third-administration group received the 2000-mg/k.g dose. Since no animal died
after the third administration, the fourth-administration group received the 2000-mg/kg dose again. For
administration, single oral gavage with a metal starnach tube was selected. Observation of mortality
and general condition was performed for 14 days after administration.
The results are as follows.
1. 300-mg/kg dose (the first- and second-administration groups)
No animal died, and no abnormalities in appearance or behaviors were noted in general-condition
observation. The body weights satisfactorily increascd for 14 days. Necropsy revealed no
abnormalities in any appearance ofthe surface, orifice, or argans or lymph nodes in cranial,
thoracic, or abdominal cavity.
2. 2000-mg/kg dose (the third- and fourth-administration groups)
No deaths occurred. In general condition, 1 animal ofthe third-administration group showed
slowness in behavior from 30 minutcs after administration followed by abnormal gait; these signs
recovercd by 2 hours after administration. In the other animals, no abnormalities were found in
general condition, appearance or behavior. The body weights satisfactorily increased. Necropsy
revealed no abnormalities in any ofthe surface, orifice, or argans or lymph nodes in cranial,
thoracic, or abdominal cavity.
Based on the above results, the test substance induced toxicity at the dose of 2000 mg/kg, but not
lethal. In conclusion, the LD50 is greater than 2000 mg/kg, and it should be classified in Class 5 in
GHS Classification.
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