Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-424-6 | CAS number: 106-69-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: oral
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Experimental Toxicity and Metabolism of 1,2,6-Hexanetriol
- Author:
- Smyth HF et al.
- Year:
- 1 969
- Bibliographic source:
- Toxicol. Applied Pharmacol., 15: 282-86
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Hexane-1,2,6-triol
- EC Number:
- 203-424-6
- EC Name:
- Hexane-1,2,6-triol
- Cas Number:
- 106-69-4
- Molecular formula:
- C6H14O3
- IUPAC Name:
- hexane-1,2,6-triol
- Test material form:
- liquid
- Details on test material:
- QSAR method by using calculation
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CFN
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Strain: Rat / CFN
- Number and sex: 432 animals (216 males and 216 females)
ENVIRONMENTAL CONDITIONS:
- Diet: Purina ® Laboratory Chow Meal
- Water: tab water ad libitum
- Housing in groups of 4 animals of the same sex in wire-bottom galvanized cages
Administration / exposure
- Route of administration:
- oral: feed
- Details on exposure:
- Food consumption was measured for each cage by 28-day periods.
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 2 years
- Frequency of treatment:
- daily
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0.25 other: % in diet
- Dose / conc.:
- 0.5 other: % in diet
- Dose / conc.:
- 1 other: % in diet
- Dose / conc.:
- 2 other: % in diet
- Dose / conc.:
- 5 other: % in diet
- No. of animals per sex per dose:
- 36 males and females per dose, 20 males and females per dose were treated for the full 2-year period
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Four to 8 of each sex at each dosage level were designated in advance for sacrifice after 6, 9, and 12 months. Twenty of each sex were maintained until death or for the entire period.
Examinations
- Observations and examinations performed and frequency:
- Rats were weighed biweekly for 1 month, then every 4 weeks. All animals dying were autopsied to judge cause of death. Hematocrit values were determined 6 times on 10 male rats receiving the 2 highest and the control dosages.
- Sacrifice and pathology:
- From rats dying spontaneously and from all rats sacrificed, sections of 17 tissues were taken for microscopic study. Tissues were fixed in buffered formalin. All tissues were studied only from control rats and those on 5 % diets. In addition to hematoxylin and eosin stain applied to all, selected liver and kidney sections were stained for lipoid droplets with Sudan IV, and with periodic acid-Schiff stain for reticulin fibers. Selected Iivers were stained with Best's carminic acid stain for glycogen. Selective spleen sections were stained with Turnbull Blue for hemosiderin, and pancreas tissues for beta-cell changes using the Liisberg chromotrope 2R-phosphotungstic acid technique.
- Statistics:
- All numerical data were evaluated by Student's t-test, analysis of variance, or chi square with Yate's correction for continuity as appropriate.
Results and discussion
Results of examinations
- Mortality:
- mortality observed, non-treatment-related
- Description (incidence):
- No rat died of toxic eff ect, evidence of a sufficient infection or accident being found for each victim.
Survivors among 40 rats in each group after an exposure period of 2 years were fewest among controls (15), greatest among those with 0.5 % test item in the diet (39), and intermediate at 5 % in the diet (22). Mean expectation of life at birth was not reduced by treatment, ranging from
633 and 694 days formale and female controls to 681 and 746 days at 5 % in the diet. - Body weight and weight changes:
- not specified
- Description (incidence and severity):
- Body weight gain among males at 5 % in the diet was 90 % that of controls, a statistically significant reduction. Other groups did not differ from the controls.
- Organ weight findings including organ / body weight ratios:
- not specified
- Description (incidence and severity):
- After two years there was no significant difference from controls in mean weights ± standard deviations of liver or kidneys as a percentage of body weight.
However, there was a transient early effect on kidney but not liver weight, male kidneys being heavier than controls at 6, 9, and 12 months on 5% in the diet; female kidneys were heavier at 6, 9, and 12 months in 5%, 6 months at 2%, 6 and 9 months at 1%. - Histopathological findings: non-neoplastic:
- not specified
- Description (incidence and severity):
- In the kidneys there was an increase in diffuse tubular cloudy swelling at 12 months in rats on 5, 2, and 1% not seen at other times or levels, and an increase in diffuse congestion of glomeruli at 12 months only in rats of the 5% group. In the livers there was diffuse parenchymatous cloudy swelling at 24 months in rats on 5 and 2% levels; and in the pancreas an increase in acinar cloudy swelling at 24 months on the 5% level.
- Histopathological findings: neoplastic:
- effects observed, non-treatment-related
- Description (incidence and severity):
- Neoplasms were found in 44 of the 240 rats observed for 2 years of dosing or until earlier death. Twenty-one of these were the pituitary adenomas which were found increasingly often in CFN rats in different laboratories at the time (1960-62) the feeding study was done, 5 among controls, 2-4 in other groups. The remaining neoplasms were widely distributed in location and kind, equally among the dosage groups. The number of rats with neoplasms varied from 6 to 10 in the different dosage groups, 10 at the 5 % level, 9 in the control group.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.