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Diss Factsheets
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EC number: 943-665-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 24 March 2016 and 08 April 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 22 January 2001
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Version / remarks:
- 30 May 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: sponsor Lot/Batch number 5399661C10
- Expiration date of the lot/batch: 24 February 2020
- Purity test date:
RADIOLABELLING INFORMATION (if applicable)
- Radiochemical purity:
- Specific activity:
- Locations of the label:
- Expiration date of radiochemical substance:
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature in the dark
- Stability under test conditions:
- Solubility and stability of the test substance in the solvent/vehicle:
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium:
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing:
- Preliminary purification step (if any):
- Final dilution of a dissolved solid, stock liquid or gel:
- Final preparation of a solid:
FORM AS APPLIED IN THE TEST (if different from that of starting material)
OTHER SPECIFICS: - Radiolabelling:
- no
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: HPLC
- Type: Agilent Technologies 1200 series
- Type, material and dimension of analytical (guard) column: Waters XSelect HSS Cyano 5 mm (150 x 4.6 mm id)
- Detection system: UV detector wavelength : 210 nm
MOBILE PHASES
- Type: Reverse phase: Methanol: purified water (55:45 v/v) Ramp to 100% Methanol post 30 minutes (over 30 mins) for samples only
- Experiments with additives carried out on separate columns: no
- pH: 6.9
- Solutes for dissolving test and reference substances: methanol
DETERMINATION OF DEAD TIME
- Method: by inert substances which are not retained by the column - formamide
REFERENCE SUBSTANCES
- Identity: Acetanilide, Phenol, Atrazine, Isoproturon, Triademinol, Linuron, Napthalene, Endosulfan-diol, Fenthion, alpha-Endpsulfan, Phenanthrene, Diclofop-methyl, DDT (Table 1 below)
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 26.25 µg
- Quantity of reference substances: 1 - 1.6 µg
- Intervals of calibration:
REPETITIONS
- Number of determinations: 2
EVALUATION
- Calculation of capacity factors k': yes
- Calculation of retention times: no
- Determination of the log Koc value: yes - Key result
- Sample No.:
- #1
- Type:
- Koc
- Value:
- ca. 17.8 - < 427 000 dimensionless
- pH:
- 7
- Temp.:
- 30 °C
- Matrix:
- Cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used.
- Remarks on result:
- other: pH nominal 7 (not n=measured because
- Remarks:
- test substance has no ionisable groups
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: See Table 2
- Details of fitted regression line (log k' vs. log Koc): Y = 0.3368x - 0.7311
- Graph of regression line attached: no
- Average retention data for test substance: 21.65 mins - Validity criteria fulfilled:
- yes
- Conclusions:
- The test item has a range of adsorption coefficient results, with the main peak by area percent being present at an adsorption coefficient of 1.24 x 105 (log10 Koc 5.09).
The adsorption coefficient (Koc) of the test item has been determined to have a range of <17.8 to > 4.27 x 105, log10 Koc <1.25 to >5.63, with the largest peak by area percent being represented by an adsorption coefficient 1.24 x 105, log10 Koc 5.09. - Executive summary:
The adsorption coefficient of RD 14153 has been determined to be have a range of <17.8 to >4.27 x 105. log10 Koc <1.25 to >5.63, with the largest peak by area being representes by an adsorption coefficient of 1.24 x 105, log10 Koc 5.09. using the HPLC screening method.
Reference
Table 2: Retention times, capacity factors and log10 Koc values for reference standards.
Standard | Mean retention time (mins) | Capacity factor (k') | Log10 k' | Log10 Koc |
Acetanilide | 2.711 | 0.365 | -0.437 | 1.25 |
Phenol | 2.566 | 0.292 | -0.535 | 1.32 |
Atrazine | 3.738 | 0.883 | -5.42 x 10-2 | 1.81 |
Isoproturon | 3.984 | 1.01 | 2.64 x 10-3 | 1.86 |
Triadimenol | 5.320 | 1.68 | 0.225 | 2.40 |
Linuron | 5.433 | 1.74 | 0.240 | 2.59 |
Naphthalene | 4.696 | 1.37 | 0.135 | 2.75 |
Endosulfan-diol | 6.650 | 2.35 | 0.371 | 3.02 |
Fenthion | 8.057 | 3.06 | 0.485 | 3.31 |
alpha-Endosulfan | 11.300 | 4.695 | 0.671 | 4.09 |
Phenanthrene | 8.729 | 3.40 | 0.531 | 4.09 |
Diclofop-methyl | 12.234 | 5.16 | 0.713 | 4.20 |
DDT | 24.461 | 11.3 | 1.05 | 5.63 |
Table 3: Retention times, capacity factor, log10 and Koc values for RD14153
Peak | Mean retention time (mins) | Mean capacity factor (k') | Mean Log10 Koc | Adsorption coeff. | Mean % area |
1 | 2.182 | 9.90 x 10-2 | <1.25 | <17.8 | 28.8 |
2 | 21.137 | 9.65 | 5.09 | 1.24 x 105 | 60.3 |
3 | 43.480 | 20.9 | >5.63 | >4.27 x 105 | 6.43 |
4 | 47.797 | 23.1 | >5.63 | >4.27 x 105 | 1.55 |
5 | 49.770 | 24.1 | >5.63 | >4.27 x 105 | 0.40 |
6 | 50.501 | 24.4 | >5.63 | >4.27 x 105 | 1.48 |
7 | 53.352 | 25.9 | >5.63 | >4.27 x 105 | 1.08 |
Description of key information
The adsorption coefficient of RD 14153 has been determined to be have a range of <17.8 to >4.27 x 105. log10Koc<1.25 to >5.63, with the largest peak by area being representes by an adsorption coefficient of 1.24 x 105, log10Koc5.09. using the HPLC screening method.
Key value for chemical safety assessment
- Koc at 20 °C:
- 123 027
Additional information
[LogKoc: 5.09]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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