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EC number: 233-251-1 | CAS number: 10101-50-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to terrestrial arthropods: long-term
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See the read-across report attached in Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 100 mg/kg bw
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- other: Mn in soil
- Basis for effect:
- mortality
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 067 mg/kg bw
- Nominal / measured:
- not specified
- Conc. based on:
- other: Mn
- Basis for effect:
- reproduction
- Endpoint:
- toxicity to terrestrial arthropods: long-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Justification for type of information:
- See the read-across report attached in Section 13.
- Qualifier:
- according to guideline
- Guideline:
- ISO 11267 (Inhibition of Reproduction of Collembola by Soil Pollutants)
- Deviations:
- yes
- Remarks:
- The method was adapted for use with natural soils
- GLP compliance:
- not specified
- Application method:
- soil
- Analytical monitoring:
- yes
- Details on preparation and application of test substrate:
- The soil was a natural soil containing 1.2% organic matter.
- Test organisms (species):
- Folsomia candida
- Animal group:
- Acari (soil-dwelling predatory mite)
- Study type:
- laboratory study
- Limit test:
- no
- Total exposure duration:
- 28 d
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 100 mg/kg bw
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- other: Mn in soil
- Basis for effect:
- mortality
- Duration:
- 28 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 067 mg/kg bw
- Conc. based on:
- other: Mn
- Basis for effect:
- reproduction
- Validity criteria fulfilled:
- yes
- Remarks:
- apart from adult mortality greater than 30% at concentrations higher than 1667 mg/kg and higher concentrations and mean number of juveniles was less than 80 at concentrations higher than 1100 mg/kg. Not considered to affect choice of NOEC.
- Conclusions:
- Under the conditions of the study, the No Observable Effect Concentration (NOEC) is 1067 mg Mn/kg dw.
Referenceopen allclose all
The natural background Mn concentration determined in the negative control treatment was 94 mg kg-I. Total extractable Mn concentrations (in excess of background) in the experimental treatments ranged from 99 to 140% and averaged 111% of nominal. Exchangeable Mn fraction expressed as percent of total concentration increased with increasing soil Mn loads.
Range finding test:
Manganese sulphate monohydrate (MnSO4·H2O) was used to conduct a range finding test. Adult survival and juvenile production decreased significantly at 5,000 mg/kg. There were no juveniles above the 5,000 mg/kg treatment concentration.
Definitive test:
Manganese did not affect (P = 0.168) adult springtail survival at the 1667 mg/kg concentration. Adult survival was significantly reduced (P = 0.0001) at 2444 mg/kg. The bounded NOEC for juvenile production was 1067 mg/kg (P=0.070). The bounded LOEC for juvenile production was 1100 mg/kg (P=0.025). No juveniles were produced in 2444 mg/kg treatment. The
EC20 and EC50 values for Mn for juvenile production were 1209 and 1663 mg/kg, respectively.
Table 1: Nominal and measured concentrations of manganese
Nominal (mg/kg) |
Measured (mg/kg) |
Corrected recovery (%) |
0 |
94 |
0 |
287 |
386 |
102 |
500 |
633 |
108 |
695 |
1067 |
140 |
966 |
1100 |
104 |
1343 |
1667 |
117 |
1867 |
2444 |
126 |
2594 |
2836 |
106 |
3606 |
3667 |
99 |
5056 |
5056 |
99 |
Description of key information
Under the conditions of the study, the No Observable Effect Concentration (NOEC) for the read across source substance is 1 067 mg Mn/kg dw.
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for soil dwelling arthropods:
- 1 067 mg/kg soil dw
Additional information
Under the conditions of the study, the No Observable Effect Concentration (NOEC) for the read across source substance is 1 067 mg Mn/kg dw. The study was awarded a reliability score of 2 in accordance with the criteria set forth by Klimisch et al. (1997).
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